TY - JOUR
T1 - Predictors of outcomes in the treatment of urge urinary incontinence in women
AU - Richter, Holly E.
AU - Burgio, Kathryn L.
AU - Chai, Toby C.
AU - Kraus, Stephen R.
AU - Xu, Yan
AU - Nyberg, Lee
AU - Brubaker, Linda
N1 - Funding Information:
Supported by cooperative agreements from the National Institute of Diabetes and Digestive and Kidney Diseases, U01 DK58225, U01 DK58229, U01 DK58234, U01 DK58231, U01 DK60379, U01 DK60380, U01 DK60393, U01 DK60395, U01 DK60397, and 60401; support was also provided by the National Institute of Child Health and Human Development and Office of Research in Women’s Health, National Institutes of Health. This trial is registered at Clinicaltrials.gov NCT00064662. For a list of UITN investigators, see Appendix 1.
PY - 2009
Y1 - 2009
N2 - Introduction and hypothesis: Women with urge predominant urinary incontinence received active intervention (drug therapy alone or combined with behavioral therapy) for 10 weeks, then stopped all therapy and were followed for 6 months more. In this planned secondary analysis, we aimed to identify predictors of therapeutic success at 10 weeks (≥70% reduction in incontinence) and of ability to discontinue treatment and sustain improvements 6 months later. Methods: Using data from 307 women, we performed logistic regression to identify predictors for outcomes described above. Results: After controlling for group, only younger age was associated with short-term success (OR 0.8, 95% CI 0.66, 0.96). At 6 months, controlling for group and short-term outcome, only greater anterior vaginal wall prolapse was associated with successful discontinuation (POP-Q point Aa; OR 1.33, 95% CI 1.03, 1.7). Conclusion: These findings are not of sufficient strength to justify withholding conservative therapies but might be used to promote realistic expectations when counseling patients.
AB - Introduction and hypothesis: Women with urge predominant urinary incontinence received active intervention (drug therapy alone or combined with behavioral therapy) for 10 weeks, then stopped all therapy and were followed for 6 months more. In this planned secondary analysis, we aimed to identify predictors of therapeutic success at 10 weeks (≥70% reduction in incontinence) and of ability to discontinue treatment and sustain improvements 6 months later. Methods: Using data from 307 women, we performed logistic regression to identify predictors for outcomes described above. Results: After controlling for group, only younger age was associated with short-term success (OR 0.8, 95% CI 0.66, 0.96). At 6 months, controlling for group and short-term outcome, only greater anterior vaginal wall prolapse was associated with successful discontinuation (POP-Q point Aa; OR 1.33, 95% CI 1.03, 1.7). Conclusion: These findings are not of sufficient strength to justify withholding conservative therapies but might be used to promote realistic expectations when counseling patients.
KW - Predictors of outcome
KW - Randomized trial
KW - Urge urinary incontinence
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U2 - 10.1007/s00192-009-0805-1
DO - 10.1007/s00192-009-0805-1
M3 - Article
C2 - 19183825
AN - SCOPUS:63749098726
VL - 20
SP - 489
EP - 497
JO - International Urogynecology Journal and Pelvic Floor Dysfunction
JF - International Urogynecology Journal and Pelvic Floor Dysfunction
SN - 0937-3462
IS - 5
ER -