Predictors of insulin sensitivity and secretion in pregnancy

M. Berkus, O. Langer, T. Siler-Khodr

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: Several factors have been suggested as predictors for the severity of CDM. However, these factors were never correlated with the actual pathoigenesis of GDM. Therefore, we sought to determine the relationship between these GDM predictors and, insulin secretion patterns and sensitivity (Si) in pregnancy METHOD: 106 piegnani patients underwent a Minimal Model stndy during the early 3rd trimester. 40 samples were obtained to determine glucose and insulin, in order to calculate S; and insulin secretion. Glucose was determined using the glucose oxidase method, while insulin was measured witli a double antibod\ technique. Several independent risk factors for the occurrence of GDM were then examined to determine their relationship to the insulin sensitivm index (Sf 1st phase insulin response). RESULTS: In the stuch there was a significant negative correlation between an low S, and insulin response, i.e. low sensitivity index and: BMI(p < .05); tasting glucose level (p < .04); 1-h.nit (p < .01} £S-hour (p < .02) GTT values; and GTT periodicity (p < .03). but no relationship with: age; pariu; total insulin dose; birthweight ol largest sibling; 2-hour GTT value; or fasting insulin level. CONCLUSION: There was a significant telalionship between maternal si/e, GTT values and the paihogenesis of GDM (low St and insulin output). Traditional risk factors, such as age, parity, insulin need, previous macrosomia. failed to predict abnormal glucose metabolism.

Original languageEnglish (US)
Pages (from-to)S172
JournalActa Diabetologica Latina
Issue number1 PART II
StatePublished - 1997

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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