Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings

G. C. LEE, R. G. HALL Hall, N. K. BOYD, S. D. DALLAS, L. C. DU, L. B. TREVIÑO, C. RETZLOFF, S. B. TREVIÑO, K. A. LAWSON, J. P. WILSON, R. J. OLSEN, Y. WANG, Chris Frei

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Skin and soft tissue infections (SSTIs) due to Staphylococcus aureus have become increasingly common in the outpatient setting; however, risk factors for differentiating methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) SSTIs are needed to better inform antibiotic treatment decisions. We performed a case-case-control study within 14 primary-care clinics in South Texas from 2007 to 2015. Overall, 325 patients [S. aureus SSTI cases (case group 1, n = 175); MRSA SSTI cases (case group 2, n = 115); MSSA SSTI cases (case group 3, n = 60); uninfected control group (control, n = 150)] were evaluated. Each case group was compared to the control group, and then qualitatively contrasted to identify unique risk factors associated with S. aureus, MRSA, and MSSA SSTIs. Overall, prior SSTIs [adjusted odds ratio (aOR) 7·60, 95% confidence interval (CI) 3·31–17·45], male gender (aOR 1·74, 95% CI 1·06–2·85), and absence of healthcare occupation status (aOR 0·14, 95% CI 0·03–0·68) were independently associated with S. aureus SSTIs. The only unique risk factor for community-associated (CA)-MRSA SSTIs was a high body weight (⩾110 kg) (aOR 2·03, 95% CI 1·01–4·09).

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalEpidemiology and Infection
DOIs
StateAccepted/In press - Aug 4 2016

Fingerprint

Soft Tissue Infections
Methicillin
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Primary Health Care
Skin
Odds Ratio
Confidence Intervals
Control Groups
Occupations
Case-Control Studies
Outpatients
Body Weight
Anti-Bacterial Agents
Delivery of Health Care

Keywords

  • Epidemiology
  • soft tissue infections
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

Cite this

Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings. / LEE, G. C.; HALL Hall, R. G.; BOYD, N. K.; DALLAS, S. D.; DU, L. C.; TREVIÑO, L. B.; RETZLOFF, C.; TREVIÑO, S. B.; LAWSON, K. A.; WILSON, J. P.; OLSEN, R. J.; WANG, Y.; Frei, Chris.

In: Epidemiology and Infection, 04.08.2016, p. 1-7.

Research output: Contribution to journalArticle

LEE, GC, HALL Hall, RG, BOYD, NK, DALLAS, SD, DU, LC, TREVIÑO, LB, RETZLOFF, C, TREVIÑO, SB, LAWSON, KA, WILSON, JP, OLSEN, RJ, WANG, Y & Frei, C 2016, 'Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings', Epidemiology and Infection, pp. 1-7. https://doi.org/10.1017/S0950268816001709
LEE, G. C. ; HALL Hall, R. G. ; BOYD, N. K. ; DALLAS, S. D. ; DU, L. C. ; TREVIÑO, L. B. ; RETZLOFF, C. ; TREVIÑO, S. B. ; LAWSON, K. A. ; WILSON, J. P. ; OLSEN, R. J. ; WANG, Y. ; Frei, Chris. / Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings. In: Epidemiology and Infection. 2016 ; pp. 1-7.
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AU - BOYD, N. K.

AU - DALLAS, S. D.

AU - DU, L. C.

AU - TREVIÑO, L. B.

AU - RETZLOFF, C.

AU - TREVIÑO, S. B.

AU - LAWSON, K. A.

AU - WILSON, J. P.

AU - OLSEN, R. J.

AU - WANG, Y.

AU - Frei, Chris

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N2 - Skin and soft tissue infections (SSTIs) due to Staphylococcus aureus have become increasingly common in the outpatient setting; however, risk factors for differentiating methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) SSTIs are needed to better inform antibiotic treatment decisions. We performed a case-case-control study within 14 primary-care clinics in South Texas from 2007 to 2015. Overall, 325 patients [S. aureus SSTI cases (case group 1, n = 175); MRSA SSTI cases (case group 2, n = 115); MSSA SSTI cases (case group 3, n = 60); uninfected control group (control, n = 150)] were evaluated. Each case group was compared to the control group, and then qualitatively contrasted to identify unique risk factors associated with S. aureus, MRSA, and MSSA SSTIs. Overall, prior SSTIs [adjusted odds ratio (aOR) 7·60, 95% confidence interval (CI) 3·31–17·45], male gender (aOR 1·74, 95% CI 1·06–2·85), and absence of healthcare occupation status (aOR 0·14, 95% CI 0·03–0·68) were independently associated with S. aureus SSTIs. The only unique risk factor for community-associated (CA)-MRSA SSTIs was a high body weight (⩾110 kg) (aOR 2·03, 95% CI 1·01–4·09).

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