Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons

Alberto O. Chavez, Amalia Gastaldelli, Rodolfo Guardado-Mendoza, Juan C. Lopez-Alvarenga, M. Michelle Michelle, M. Elizabeth Elizabeth, GianPio P. Sorice, Francesca Casiraghi, Alberto Davalli, Raúl A. Bastarrachea, Anthony G. Comuzzie, Ralph A Defronzo, Franco Folli

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted by adiposity, metabolic markers of obesity and impaired glucose metabolism (i.e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available. Methods: We studied a population of twenty baboons with the euglycemic clamp technique to characterize a population of obese nondiabetic, insulin resistant baboons, and used a multivariate linear regression analysis (adjusted for gender) to test different predictive models of insulin sensitivity (insulin-stimulated glucose uptake = Rd) using abdominal circumference and fasting plasma insulin. Alternatively, we tested in a separate baboon population (n = 159), a simpler model based on body weight and fasting plasma glucose to predict the whole-body insulin sensitivity (Rd/SSPI) derived from the clamp. Results: In the first model, abdominal circumference explained 59% of total insulin mediated glucose uptake (Rd). A second model, which included fasting plasma insulin (log transformed) and abdominal circumference, explained 64% of Rd. Finally, the model using body weight and fasting plasma glucose explained 51% of Rd/SSPI. Interestingly, we found that percent body fat was directly correlated with the adipocyte insulin resistance index (r = 0.755, p < 0.0001). Conclusion: In baboons, simple morphometric measurements of adiposity/ obesity, (i.e. abdominal circumference), plus baseline markers of glucose/lipid metabolism, (i.e. fasting plasma glucose and insulin) provide a feasible method to screen and identify overweight/obese insulin resistant baboons for inclusion in interventional studies aimed to study human obesity, insulin resistance and type 2 diabetes mellitus.

Original languageEnglish (US)
Article number22
JournalCardiovascular Diabetology
Volume8
DOIs
StatePublished - Apr 23 2009

Fingerprint

Papio
Insulin Resistance
Obesity
Insulin
Glucose
Fasting
Glucose Clamp Technique
Adiposity
Adipose Tissue
Body Weight
Population
Abdominal Obesity
Lipid Metabolism
Adipocytes
Type 2 Diabetes Mellitus
Primates
Linear Models
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Chavez, A. O., Gastaldelli, A., Guardado-Mendoza, R., Lopez-Alvarenga, J. C., Michelle, M. M., Elizabeth, M. E., ... Folli, F. (2009). Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons. Cardiovascular Diabetology, 8, [22]. https://doi.org/10.1186/1475-2840-8-22

Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons. / Chavez, Alberto O.; Gastaldelli, Amalia; Guardado-Mendoza, Rodolfo; Lopez-Alvarenga, Juan C.; Michelle, M. Michelle; Elizabeth, M. Elizabeth; Sorice, GianPio P.; Casiraghi, Francesca; Davalli, Alberto; Bastarrachea, Raúl A.; Comuzzie, Anthony G.; Defronzo, Ralph A; Folli, Franco.

In: Cardiovascular Diabetology, Vol. 8, 22, 23.04.2009.

Research output: Contribution to journalArticle

Chavez, AO, Gastaldelli, A, Guardado-Mendoza, R, Lopez-Alvarenga, JC, Michelle, MM, Elizabeth, ME, Sorice, GP, Casiraghi, F, Davalli, A, Bastarrachea, RA, Comuzzie, AG, Defronzo, RA & Folli, F 2009, 'Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons', Cardiovascular Diabetology, vol. 8, 22. https://doi.org/10.1186/1475-2840-8-22
Chavez, Alberto O. ; Gastaldelli, Amalia ; Guardado-Mendoza, Rodolfo ; Lopez-Alvarenga, Juan C. ; Michelle, M. Michelle ; Elizabeth, M. Elizabeth ; Sorice, GianPio P. ; Casiraghi, Francesca ; Davalli, Alberto ; Bastarrachea, Raúl A. ; Comuzzie, Anthony G. ; Defronzo, Ralph A ; Folli, Franco. / Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons. In: Cardiovascular Diabetology. 2009 ; Vol. 8.
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abstract = "Background: Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted by adiposity, metabolic markers of obesity and impaired glucose metabolism (i.e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available. Methods: We studied a population of twenty baboons with the euglycemic clamp technique to characterize a population of obese nondiabetic, insulin resistant baboons, and used a multivariate linear regression analysis (adjusted for gender) to test different predictive models of insulin sensitivity (insulin-stimulated glucose uptake = Rd) using abdominal circumference and fasting plasma insulin. Alternatively, we tested in a separate baboon population (n = 159), a simpler model based on body weight and fasting plasma glucose to predict the whole-body insulin sensitivity (Rd/SSPI) derived from the clamp. Results: In the first model, abdominal circumference explained 59{\%} of total insulin mediated glucose uptake (Rd). A second model, which included fasting plasma insulin (log transformed) and abdominal circumference, explained 64{\%} of Rd. Finally, the model using body weight and fasting plasma glucose explained 51{\%} of Rd/SSPI. Interestingly, we found that percent body fat was directly correlated with the adipocyte insulin resistance index (r = 0.755, p < 0.0001). Conclusion: In baboons, simple morphometric measurements of adiposity/ obesity, (i.e. abdominal circumference), plus baseline markers of glucose/lipid metabolism, (i.e. fasting plasma glucose and insulin) provide a feasible method to screen and identify overweight/obese insulin resistant baboons for inclusion in interventional studies aimed to study human obesity, insulin resistance and type 2 diabetes mellitus.",
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AU - Lopez-Alvarenga, Juan C.

AU - Michelle, M. Michelle

AU - Elizabeth, M. Elizabeth

AU - Sorice, GianPio P.

AU - Casiraghi, Francesca

AU - Davalli, Alberto

AU - Bastarrachea, Raúl A.

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AU - Defronzo, Ralph A

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N2 - Background: Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted by adiposity, metabolic markers of obesity and impaired glucose metabolism (i.e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify obese insulin resistant baboons for inclusion in interventional studies is not available. Methods: We studied a population of twenty baboons with the euglycemic clamp technique to characterize a population of obese nondiabetic, insulin resistant baboons, and used a multivariate linear regression analysis (adjusted for gender) to test different predictive models of insulin sensitivity (insulin-stimulated glucose uptake = Rd) using abdominal circumference and fasting plasma insulin. Alternatively, we tested in a separate baboon population (n = 159), a simpler model based on body weight and fasting plasma glucose to predict the whole-body insulin sensitivity (Rd/SSPI) derived from the clamp. Results: In the first model, abdominal circumference explained 59% of total insulin mediated glucose uptake (Rd). A second model, which included fasting plasma insulin (log transformed) and abdominal circumference, explained 64% of Rd. Finally, the model using body weight and fasting plasma glucose explained 51% of Rd/SSPI. Interestingly, we found that percent body fat was directly correlated with the adipocyte insulin resistance index (r = 0.755, p < 0.0001). Conclusion: In baboons, simple morphometric measurements of adiposity/ obesity, (i.e. abdominal circumference), plus baseline markers of glucose/lipid metabolism, (i.e. fasting plasma glucose and insulin) provide a feasible method to screen and identify overweight/obese insulin resistant baboons for inclusion in interventional studies aimed to study human obesity, insulin resistance and type 2 diabetes mellitus.

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