Predictive factors for the rate of engraftment of neuroblastoma patients autotransplanted with purged marrow.

R. E. Ross, E. K. Jeter, Y. Gazitt, J. Laver

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Predictive values for patient engraftment in neuroblastoma have not been defined. By analyzing the parameters available to us at the time of harvest and post-harvest, we found that the MNC/kg after purging demonstrated significant correlation with patient engraftment as measured by the patient's time to reach a WBC count of 1,000/microL and an ANC count of 500/microL. Platelet and red cell independence was difficult to measure as some of these patients remain platelet- and red cell-dependent for extended periods of time. Platelet refractoriness, alloimmunization, infection and many other factors can delay platelet and red cell recovery following transplantation. A larger number of patients is needed to assess a correlation between the parameters analyzed and platelet and red cell recovery, as well as to validate our observation with myeloid recovery.

Original languageEnglish (US)
Pages (from-to)139-143
Number of pages5
JournalProgress in clinical and biological research
Volume389
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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