Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data

David J. Brunswick, Jay D. Amsterdam, Joseph Mendels, Stephen L. Stern

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.

Original languageEnglish (US)
Pages (from-to)605-610
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume25
Issue number5 PART 1
StatePublished - May 1979
Externally publishedYes

Fingerprint

Desipramine
Imipramine
Tricyclic Antidepressive Agents
Healthy Volunteers
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Brunswick, D. J., Amsterdam, J. D., Mendels, J., & Stern, S. L. (1979). Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data. Clinical Pharmacology and Therapeutics, 25(5 PART 1), 605-610.

Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data. / Brunswick, David J.; Amsterdam, Jay D.; Mendels, Joseph; Stern, Stephen L.

In: Clinical Pharmacology and Therapeutics, Vol. 25, No. 5 PART 1, 05.1979, p. 605-610.

Research output: Contribution to journalArticle

Brunswick, DJ, Amsterdam, JD, Mendels, J & Stern, SL 1979, 'Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data', Clinical Pharmacology and Therapeutics, vol. 25, no. 5 PART 1, pp. 605-610.
Brunswick, David J. ; Amsterdam, Jay D. ; Mendels, Joseph ; Stern, Stephen L. / Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data. In: Clinical Pharmacology and Therapeutics. 1979 ; Vol. 25, No. 5 PART 1. pp. 605-610.
@article{43c7df23db934475ad38c1f05f9e8d16,
title = "Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data",
abstract = "Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a {"}therapeutic{"} dosage regimen without delay.",
author = "Brunswick, {David J.} and Amsterdam, {Jay D.} and Joseph Mendels and Stern, {Stephen L.}",
year = "1979",
month = "5",
language = "English (US)",
volume = "25",
pages = "605--610",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "5 PART 1",

}

TY - JOUR

T1 - Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data

AU - Brunswick, David J.

AU - Amsterdam, Jay D.

AU - Mendels, Joseph

AU - Stern, Stephen L.

PY - 1979/5

Y1 - 1979/5

N2 - Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.

AB - Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.

UR - http://www.scopus.com/inward/record.url?scp=0018378884&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018378884&partnerID=8YFLogxK

M3 - Article

C2 - 436362

AN - SCOPUS:0018378884

VL - 25

SP - 605

EP - 610

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 5 PART 1

ER -