Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data

David J. Brunswick, Jay D. Amsterdam, Joseph Mendels, Stephen L. Stern

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.

Original languageEnglish (US)
Pages (from-to)605-610
Number of pages6
JournalClinical Pharmacology and Therapeutics
Volume25
Issue number5 PART 1
DOIs
StatePublished - May 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data'. Together they form a unique fingerprint.

  • Cite this