Abstract
Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 605-610 |
| Number of pages | 6 |
| Journal | Clinical Pharmacology and Therapeutics |
| Volume | 25 |
| Issue number | 5 PART 1 |
| State | Published - May 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Pharmacology
Cite this
Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data. / Brunswick, David J.; Amsterdam, Jay D.; Mendels, Joseph; Stern, Stephen L.
In: Clinical Pharmacology and Therapeutics, Vol. 25, No. 5 PART 1, 05.1979, p. 605-610.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Prediction of steady-state imipramine and desmethylimipramine plasma concentrations from single-dose data
AU - Brunswick, David J.
AU - Amsterdam, Jay D.
AU - Mendels, Joseph
AU - Stern, Stephen L.
PY - 1979/5
Y1 - 1979/5
N2 - Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.
AB - Tricyclic antidepressant plasma levels were measured in patients and healthy subjects after a single dose of desmethylimipramine (DMI) or imipramine (IMI) and after chronic dosing to steady states. Tricyclic plasma levels measured 24 hr after the single oral dose correlated with steady-state plasma levels. In patients receiving DMI there was a correlation (r = 0.97, n = 10) between 24-hr and steady-state DMI levels, while in normal subjects receiving IMI the correlation was r = 0.92 (n = 20) between 24-hr and steady-state total tricyclic levels (IMI plus its metabolite, DMI). These results suggest the possibility that after a test dose of tricyclic antidepressant, a patient may be put on a "therapeutic" dosage regimen without delay.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018378884&partnerID=8YFLogxK
M3 - Article
C2 - 436362
AN - SCOPUS:0018378884
VL - 25
SP - 605
EP - 610
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 5 PART 1
ER -