Abstract
We used a virtual lesion DTI fiber tracking approach with healthy subject DTI data and simulated periventricular white matter (PVWM) lesion masks to predict the sequence of connectivity changes associated with progressive PVWM ischemia. We found that the optic radiations, inferior fronto-occipital fasciculus, inferior longitudinal fasciculus, corpus callosum, temporopontine tract and fornix were affected in early simulated ischemic injury, and that the connectivity of subcortical, cerebellar, and visual regions were significantly disrupted with increasing simulated lesion severity. The results of this study provide insights into the spatial-temporal changes of the brain structural connectome under progressive PVWM ischemia. The virtual lesion approach provides a meaningful proxy to the spatial-temporal changes of the brain's structural connectome and can be used to further characterize the cognitive sequelae of progressive PVWM ischemia in both normal aging and dementia.
Original language | English (US) |
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Article number | 100022 |
Journal | Cerebral Circulation - Cognition and Behavior |
Volume | 2 |
DOIs | |
State | Published - Jan 2021 |
Keywords
- Cerebral blood flow (CBF)
- DTI
- Functional connectivity
- Periventricular white matter (PVWM)
- Small vessel ischemic disease
- Structural connectivity
- fMRI
ASJC Scopus subject areas
- Neurology
- Cognitive Neuroscience
- Clinical Neurology
- Biological Psychiatry
- Behavioral Neuroscience