Preclinical chemotherapeutic tumor models of common childhood cancers: solid tumors, acute lymphoblastic leukemia, and disseminated neuroblastoma.

Christopher L. Morton, Rachel A. Papa, Richard B. Lock, Peter J. Houghton

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This unit presents three models used in the Pediatric Preclinical Testing Program of the National Cancer Institute (NCI) for preclinical testing of new chemical entities (NCEs), along with appropriate methods for data analysis. The first is the classical subcutaneous xenograft model used for many solid tumors, the second is the disseminated human leukemia model established by Lock and colleagues, and the third is a disseminated model of neuroblastoma that recapitulates many of the characteristics of advanced clinical disease.

Original languageEnglish (US)
Pages (from-to)Unit14.8
JournalCurrent protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief) ... [et al.]
VolumeChapter 14
DOIs
StatePublished - Dec 2007
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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