Preclinical and clinical assessment of the safety and potential efficacy of thalidomide in heart failure

Ildiko Agoston, Ziad I. Dibbs, Feng Wang, George Muller, Jerome B. Zeldis, Douglas L. Mann, Biykem Bozkurt

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Inflammatory mediators, especially tumor necrosis factor (TNF), have been implicated in heart failure (HF). Thalidomide has anti-inflammatory properties and selectively inhibits TNF. Thus far, thalidomide or thalidomide analogues have not been evaluated in patients with heart failure. Methods: Thalidomide was assessed in preclinical and clinical studies. First, isolated cardiac myocytes were pretreated with thalidomide or thalidomide analogues, and TNF production was assessed after lipopolysaccharide (LPS) provocation. Second, to determine the safety and potential efficacy of thalidomide, an open-label dose escalation safety study was conducted in seven patients with advanced heart failure. Results: Thalidomide and thalidomide analogues inhibited LPS-induced TNF biosynthesis in cardiac myocytes in a dose-dependent manner. Thalidomide analogues had a greater inhibitory effect on TNF production than did thalidomide. In patients with advanced HF, thalidomide was safe and potentially effective when used at lower doses. However, dose-limiting toxicity was observed in two patients. There was a significant increase in the 6-minute walk distance and a trend toward improvement in left ventricular ejection fraction and quality of life after 12 weeks of maintenance therapy with thalidomide. Conclusions: Taken together these results suggest that thalidomide or its derivatives may be useful in selected patients with HF. This potential needs to be studied in larger clinical trials.

Original languageEnglish (US)
Pages (from-to)306-314
Number of pages9
JournalJournal of Cardiac Failure
Volume8
Issue number5
DOIs
StatePublished - Oct 2002
Externally publishedYes

Keywords

  • Cardiac myocytes
  • Heart failure
  • Thalidomide
  • Thalidomide analogues
  • TNF

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Preclinical and clinical assessment of the safety and potential efficacy of thalidomide in heart failure'. Together they form a unique fingerprint.

  • Cite this