Precision medicine: Clarity for the complexity of dementia

Brenna Cholerton; Eric B. Larson; Joseph F. Quinn; Cyrus P. Zabetian; Ignacio F. Mata; C. Dirk Keene; Margaret Flanagan; Paul K. Crane; Thomas J. Grabowski; Kathleen S. Montine; Thomas J. Montine

doi:10.1016/j.ajpath.2015.12.001

Precision medicine: Clarity for the complexity of dementia

Brenna Cholerton, Eric B. Larson, Joseph F. Quinn, Cyrus P. Zabetian, Ignacio F. Mata, C. Dirk Keene, Margaret Flanagan, Paul K. Crane, Thomas J. Grabowski, Kathleen S. Montine, Thomas J. Montine

Research output: Contribution to journal › Review article › peer-review

47 Scopus citations

Abstract

Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

Original language	English (US)
Pages (from-to)	500-506
Number of pages	7
Journal	American Journal of Pathology
Volume	186
Issue number	3
DOIs	https://doi.org/10.1016/j.ajpath.2015.12.001
State	Published - Mar 1 2016
Externally published	Yes

ASJC Scopus subject areas

Pathology and Forensic Medicine

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10.1016/j.ajpath.2015.12.001

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title = "Precision medicine: Clarity for the complexity of dementia",

abstract = "Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.",

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AU - Cholerton, Brenna

AU - Larson, Eric B.

AU - Quinn, Joseph F.

AU - Zabetian, Cyrus P.

AU - Mata, Ignacio F.

AU - Keene, C. Dirk

AU - Flanagan, Margaret

AU - Crane, Paul K.

AU - Grabowski, Thomas J.

AU - Montine, Kathleen S.

AU - Montine, Thomas J.

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AB - Three key elements to precision medicine are stratification by risk, detection of pathophysiological processes as early as possible (even before clinical presentation), and alignment of mechanism of action of intervention(s) with an individual's molecular driver(s) of disease. Used for decades in the management of some rare diseases and now gaining broad currency in cancer care, a precision medicine approach is beginning to be adapted to cognitive impairment and dementia. This review focuses on the application of precision medicine to address the clinical and biological complexity of two common neurodegenerative causes of dementia: Alzheimer disease and Parkinson disease.

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Precision medicine: Clarity for the complexity of dementia

Abstract

ASJC Scopus subject areas

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