Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Kenneth Blum; Alphonse Kenison Roy; Arwen Podesta; Edward J. Modestino; Bruce Steinberg; Marjorie C. Gondré-Lewis; David Baron; Panayotis K. Thanos; Lisa Lott; Sampada Badgaiyan; Jessica Valdez Ponce; Brent Boyett; David Siwicki; Mark Moran; Drew Edwards; Thomas McLaughlin; Eric R. Braverman; Thomas A. Simpatico; Mary Hauser; Bernard William Downs; Rajendra D. Badgaiyan

doi:10.1017/9781108632591.031

Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Kenneth Blum, Alphonse Kenison Roy, Arwen Podesta, Edward J. Modestino, Bruce Steinberg, Marjorie C. Gondré-Lewis, David Baron, Panayotis K. Thanos, Lisa Lott, Sampada Badgaiyan, Jessica Valdez Ponce, Brent Boyett, David Siwicki, Mark Moran, Drew Edwards, Thomas McLaughlin, Eric R. Braverman, Thomas A. Simpatico, Mary Hauser, Bernard William DownsRajendra D. Badgaiyan

Department of Psychiatry & Behavioral Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.

Original language	English (US)
Title of host publication	The Cambridge Handbook of Substance and Behavioral Addictions
Publisher	Cambridge University Press
Pages	297-306
Number of pages	10
ISBN (Electronic)	9781108632591
ISBN (Print)	9781108427166
DOIs	https://doi.org/10.1017/9781108632591.031
State	Published - Jan 1 2020

Keywords

Dopamine homeostasis
GARStm
KB220 variants
Pain
Precision Addiction Management
Precision Behavioral Management
Reward Deficiency Syndrome (RDS)

ASJC Scopus subject areas

General Psychology
General Social Sciences
General Medicine

Access to Document

10.1017/9781108632591.031

Cite this

Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D., Thanos, P. K., Lott, L., Badgaiyan, S., Ponce, J. V., Boyett, B., Siwicki, D., Moran, M., Edwards, D., McLaughlin, T., Braverman, E. R., Simpatico, T. A., Hauser, M., ... Badgaiyan, R. D. (2020). Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. In The Cambridge Handbook of Substance and Behavioral Addictions (pp. 297-306). Cambridge University Press. https://doi.org/10.1017/9781108632591.031

Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. / Blum, Kenneth; Roy, Alphonse Kenison; Podesta, Arwen et al.
The Cambridge Handbook of Substance and Behavioral Addictions. Cambridge University Press, 2020. p. 297-306.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Blum, K, Roy, AK, Podesta, A, Modestino, EJ, Steinberg, B, Gondré-Lewis, MC, Baron, D, Thanos, PK, Lott, L, Badgaiyan, S, Ponce, JV, Boyett, B, Siwicki, D, Moran, M, Edwards, D, McLaughlin, T, Braverman, ER, Simpatico, TA, Hauser, M, Downs, BW & Badgaiyan, RD 2020, Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis. in The Cambridge Handbook of Substance and Behavioral Addictions. Cambridge University Press, pp. 297-306. https://doi.org/10.1017/9781108632591.031

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abstract = "Reward Deficiency Syndrome (RDS) is an umbrella term for all drug and nondrug addictive behaviors, due to a dopamine deficiency, “hypodopaminergia.” There is an opioid-overdose epidemic in the USA, which may result in or worsen RDS. A paradigm shift is needed to combat a system that is not working. This shift involves the recognition of dopamine homeostasis as the ultimate treatment of RDS via precision, genetically guided KB220 variants, called Precision Behavioral Management (PBM). Recognition of RDS as an endophenotype and an umbrella term in the future DSM 6, following the Research Domain Criteria (RDoC), would assist in shifting this paradigm.",

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Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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