Pre- and postexposure protection against human immunodeficiency virus type 1 infection mediated by a monoclonal antibody

Marie Claire Gauduin, Jeffrey T. Safrit, Raymond Weir, Michael S.C. Fung, Richard A. Koup

    Research output: Contribution to journalArticle

    59 Scopus citations

    Abstract

    Monoclonal antibody BATI23 was passively transferred into SCID mice reconstituted with human peripheral blood lymphocytes (hu-PBL-SCID) to study passive antibody protection against human immunodeficiency virus type 1 (HIV㌡) infection. BATI23 is specific for the third variable loop of the gp120 of HIV㌡LAIAnimals were protected against subsequent infection with LAI strain, but not other virus strains, when BATI23 was given 1 h before virus inoculation. This resulted in a peak serum concentration of 16 �g/mL of the antibody, which should be easily attainable in humans. In addition, postexposure protection was observed when the antibody was given within 4 h of virus inoculation. No therapeutic effect was observed, however, when BATI23 was administered after infection had been established. These results indicate that passive antibody prophylaxis against HIV-1 infection may be possible in certain clinical situations.

    Original languageEnglish (US)
    Pages (from-to)1203-1209
    Number of pages7
    JournalJournal of Infectious Diseases
    Volume171
    Issue number5
    DOIs
    StatePublished - May 1995

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Infectious Diseases

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