Pradimicin therapy of disseminated Candida tropicalis infection in the mouse

M. I. Restrepo; L. K. Najvar; A. W. Fothergill; J. R. Graybill

doi:10.1046/j.1365-280X.1998.00134.x

Pradimicin therapy of disseminated Candida tropicalis infection in the mouse

M. I. Restrepo, L. K. Najvar, A. W. Fothergill, J. R. Graybill

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

BMS 181184 (BMS), an analogue of pradimicin, was administered intravenously to neutropenic mice infected with either a fluconazole- susceptible or a fluconazole-resistant clinical isolate of Candida tropicalis. BMS prolonged survival at doses >3 mg kg^-1 day^-1, and at higher doses reduced tissue counts in mice. BMS was less potent mg for mg than amphotericin B. Combined BMS and amphotericin B were no more effective than either of the individual drugs.

Original language	English (US)
Pages (from-to)	181-184
Number of pages	4
Journal	Medical mycology
Volume	36
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-280X.1998.00134.x
State	Published - Jun 1998

Keywords

BMS
Candida tropicalis
Fluconazole
Mouse model
Pradimicin

ASJC Scopus subject areas

Infectious Diseases

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10.1046/j.1365-280X.1998.00134.x

Cite this

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title = "Pradimicin therapy of disseminated Candida tropicalis infection in the mouse",

abstract = "BMS 181184 (BMS), an analogue of pradimicin, was administered intravenously to neutropenic mice infected with either a fluconazole- susceptible or a fluconazole-resistant clinical isolate of Candida tropicalis. BMS prolonged survival at doses >3 mg kg-1 day-1, and at higher doses reduced tissue counts in mice. BMS was less potent mg for mg than amphotericin B. Combined BMS and amphotericin B were no more effective than either of the individual drugs.",

keywords = "BMS, Candida tropicalis, Fluconazole, Mouse model, Pradimicin",

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year = "1998",

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AU - Restrepo, M. I.

AU - Najvar, L. K.

AU - Fothergill, A. W.

AU - Graybill, J. R.

PY - 1998/6

Y1 - 1998/6

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AB - BMS 181184 (BMS), an analogue of pradimicin, was administered intravenously to neutropenic mice infected with either a fluconazole- susceptible or a fluconazole-resistant clinical isolate of Candida tropicalis. BMS prolonged survival at doses >3 mg kg-1 day-1, and at higher doses reduced tissue counts in mice. BMS was less potent mg for mg than amphotericin B. Combined BMS and amphotericin B were no more effective than either of the individual drugs.

KW - BMS

KW - Candida tropicalis

KW - Fluconazole

KW - Mouse model

KW - Pradimicin

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Pradimicin therapy of disseminated Candida tropicalis infection in the mouse

Abstract

Keywords

ASJC Scopus subject areas

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