Pradimicin therapy of disseminated Candida tropicalis infection in the mouse

M. I. Restrepo, L. K. Najvar, A. W. Fothergill, J. R. Graybill

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

BMS 181184 (BMS), an analogue of pradimicin, was administered intravenously to neutropenic mice infected with either a fluconazole- susceptible or a fluconazole-resistant clinical isolate of Candida tropicalis. BMS prolonged survival at doses >3 mg kg-1 day-1, and at higher doses reduced tissue counts in mice. BMS was less potent mg for mg than amphotericin B. Combined BMS and amphotericin B were no more effective than either of the individual drugs.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalMedical mycology
Volume36
Issue number3
DOIs
StatePublished - Jun 1 1998

Keywords

  • BMS
  • Candida tropicalis
  • Fluconazole
  • Mouse model
  • Pradimicin

ASJC Scopus subject areas

  • Infectious Diseases

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    Restrepo, M. I., Najvar, L. K., Fothergill, A. W., & Graybill, J. R. (1998). Pradimicin therapy of disseminated Candida tropicalis infection in the mouse. Medical mycology, 36(3), 181-184. https://doi.org/10.1046/j.1365-280X.1998.00134.x