Practical aspects of functional MRI (NMR task group #8)

Ronald R. Price, Jerry Allison, Richard J. Massoth, Geoffrey D. Clarke, Dick J. Drost

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Functional MR imaging (fMRI) based upon the Blood Oxygen Level Dependent (BOLD) effect is currently an important new tool for understanding basic brain function and specifically allowing the correlation of physiological activity with anatomical location without the use of ionizing radiation. The clinical role of fMRI is still being defined and is the subject of much research activity. In this report we present the underlying physical, technical and mathematical principals of BOLD fMRI along with descriptions of typical applications. Our purpose in this report is to provide, in addition to basic principles, an insight into the aspects of BOLD imaging, which may be used by the medical physicist to assist in the implement of fMRI procedures in either a hospital or research environment.

Original languageEnglish (US)
Pages (from-to)1892-1912
Number of pages21
JournalMedical physics
Issue number8
StatePublished - Aug 1 2002
Externally publishedYes


  • BOLD Effect
  • Functional Magnetic Resonance Imaging
  • fMRI

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging


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