PPARγ agonists and coronary atherosclerosis

Melanie S. Sulistio, Adrienne Zion, Nandish Thukral, Robert Chilton

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The prevalence of type 2 diabetes mellitus (T2DM) is growing at an alarming rate and reaching epidemic proportions, and cardiovascular disease continues to be one of the leading causes of death in the United States. The key relationship between these two diseases (knowing that T2DM is a strong risk factor for cardiovascular disease) is insulin resistance and the detrimental effect it has on macrovasculature. Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor γ agonists that are beneficial in the treatment of T2DM and have the added benefit of modifying lipid profiles. This review discusses the basic science linking insulin resistance to atherosclerosis and describes the major TZD trials in the recent literature. It also addresses the clinical implications of these studies and media scrutiny surrounding the recent controversial report that TZDs may be linked to an increased risk of myocardial infarction.

Original languageEnglish (US)
Pages (from-to)134-141
Number of pages8
JournalCurrent atherosclerosis reports
Volume10
Issue number2
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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