Abstract
Peroxisome proliferator-activated receptor (PPAR) β-null mice exhibit exacerbated epithelial cell proliferation and enhanced sensitivity to skin carcinogenesis, suggesting that ligand activation of PPARβ will inhibit keratinocyte proliferation. By using of a highly specific ligand (GW0742) and the PPARβ-null mouse model, activation of PPARβ was found to selectively induce keratinocyte terminal differentiation and inhibit keratinocyte proliferation. Additionally, GW0742 was found to be anti-inflammatory due to inhibition of myeloperoxidase activity, independent of PPARβ. These data suggest that ligand activation of PPARβ could be a novel approach to selectively induce differentiation and inhibit cell proliferation, thus representing a new molecular target for the treatment of skin disorders resulting from altered cell proliferation such as psoriasis and cancer.
Original language | English (US) |
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Pages (from-to) | 53-60 |
Number of pages | 8 |
Journal | Cell Death and Differentiation |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2006 |
Keywords
- Anti-inflammatory
- Cell proliferation
- Differentiation
- Ligand activation
- Null mouse
- Peroxisome proliferator-activated receptor-β
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology