PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

Xiaozhe Yin, Wenfeng Zeng, Bowen Wu, Luoyang Wang, Zihao Wang, Hongjian Tian, Luyao Wang, Yunhan Jiang, Ryan Clay, Xiuli Wei, Yan Qin, Fayun Zhang, Chunling Zhang, Lingtao Jin, Wei Liang

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Yin et al. reveal that tumor-derived exosomes (TDEs), as fatty acid carriers, induce a metabolic shift toward oxidative phosphorylation, driving DC immune dysfunction. Transcriptomic analysis identifies PPARα as the fatty acid sensor mediating the immunosuppressive effects of TDEs on DCs. PPARα blockade effectively restores DC function and enhances the efficacy of immunotherapy.

Original languageEnglish (US)
Article number108278
JournalCell Reports
Volume33
Issue number3
DOIs
StatePublished - Oct 20 2020
Externally publishedYes

Keywords

  • DC
  • dendritic cell
  • immune dysfunction
  • lipid metabolism
  • PPARα
  • tumor-derived exosome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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