Power of variance component linkage analysis to detect epistasis

Braxton D. Mitchell, Soumitra Ghosh, Jennifer L. Schneider, Gunther Birznieks, John Blangero

    Research output: Contribution to journalArticlepeer-review

    40 Scopus citations

    Abstract

    Variance component methods are now being used in linkage analysis to detect genes influencing complex diseases. These methods are easily extended to allow for simultaneous estimation of both the additive effects of multiple loci on phenotypic variation (conditional oligogenic analysis) and the additive interaction (epistatic) effects among loci. We performed linkage analyses on 200 of the simulated replicates in order to evaluate the power to detect the main effects of MG1 and MG2 on Q1 as well as their interaction effects. The power to detect the main effect of MG1 was moderately good, although the power to detect MG2 and the MG1 x MG2 interaction was poor.

    Original languageEnglish (US)
    Pages (from-to)1017-1022
    Number of pages6
    JournalGenetic epidemiology
    Volume14
    Issue number6
    DOIs
    StatePublished - 1997

    Keywords

    • Epistasis
    • Linkage
    • Power
    • Simulation

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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