Potentiating the benefits of melatonin through chemical functionalization: Possible impact on multifactorial neurodegenerative disorders

Annia Galano, Eduardo G. Guzmán-López, Russel J. Reiter

Research output: Contribution to journalReview articlepeer-review

Abstract

Although melatonin is an astonishing molecule, it is possible that chemistry will help in the discovery of new compounds derived from it that may exceed our expectations regarding antioxidant protection and perhaps even neuroprotection. This review briefly summarizes the significant amount of data gathered to date regarding the multiple health benefits of melatonin and related compounds. This review also highlights some of the most recent directions in the discovery of multifunctional pharmaceuticals intended to act as one-molecule multiple-target drugs with potential use in multifactorial diseases, including neurodegenerative disorders. Herein, we discuss the beneficial activities of melatonin derivatives reported to date, in addition to computational strategies to rationally design new derivatives by functionalization of the melatonin molecular framework. It is hoped that this review will promote more investigations on the subject from both experimental and theoretical perspectives.

Original languageEnglish (US)
Article number11584
JournalInternational journal of molecular sciences
Volume22
Issue number21
DOIs
StatePublished - Nov 1 2021

Keywords

  • Antioxidant
  • DNA repair
  • Free radical scavengers
  • Metal chelators
  • Multifactorial diseases
  • Multifunctional drugs
  • Neuroprotection
  • Oxidative stress

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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