Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors

Brian P. Skop, Thomas M. Brown

Research output: Contribution to journalReview articlepeer-review

173 Scopus citations

Abstract

Selective serotonin reuptake inhibitors (SSRIs) alter peripheral handling of serotonin, leading to potential side effects. Further, the majority of the body's serotonin is found outside the central nervous system. Peripheral serotonin is important in platelet aggregation and the modulation of vascular tone. SSRIs block platelet uptake and pulmonary endothelial metabolism of serotonin, and use of these agents may conceivably result in bleeding and vasospastic complications.

Original languageEnglish (US)
Pages (from-to)12-16
Number of pages5
JournalPsychosomatics
Volume37
Issue number1
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

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