Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors

Brian P. Skop; Thomas M. Brown

doi:10.1016/S0033-3182(96)71592-X

Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors

Brian P. Skop, Thomas M. Brown

Research output: Contribution to journal › Review article › peer-review

180 Scopus citations

Abstract

Selective serotonin reuptake inhibitors (SSRIs) alter peripheral handling of serotonin, leading to potential side effects. Further, the majority of the body's serotonin is found outside the central nervous system. Peripheral serotonin is important in platelet aggregation and the modulation of vascular tone. SSRIs block platelet uptake and pulmonary endothelial metabolism of serotonin, and use of these agents may conceivably result in bleeding and vasospastic complications.

Original language	English (US)
Pages (from-to)	12-16
Number of pages	5
Journal	Psychosomatics
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/S0033-3182(96)71592-X
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Psychiatry and Mental health
Arts and Humanities (miscellaneous)
Applied Psychology

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10.1016/S0033-3182(96)71592-X

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title = "Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors",

abstract = "Selective serotonin reuptake inhibitors (SSRIs) alter peripheral handling of serotonin, leading to potential side effects. Further, the majority of the body's serotonin is found outside the central nervous system. Peripheral serotonin is important in platelet aggregation and the modulation of vascular tone. SSRIs block platelet uptake and pulmonary endothelial metabolism of serotonin, and use of these agents may conceivably result in bleeding and vasospastic complications.",

author = "Skop, {Brian P.} and Brown, {Thomas M.}",

note = "Funding Information: This work was supported by the Upjohn Company. the Harvard/Brown Anxiety Disorders Research program is conducted with the participation of the following investigators: M.B. Keller. M.D. (chairperson); P.M. Lavori. Ph.D. (co-chairperson); H. Samuelson. M. Warshaw. M.S.S .. M.A. (Brown University); E. Fierman. M.D .. F. Rodriguez-Villa. M.D.(Beth Israel Hospital. Harvard Medical Schoo/); M. Rogers. M.D. (Brigham and Women' s Hospital. Harvard Medical School); R. Goisman. M.D.",

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doi = "10.1016/S0033-3182(96)71592-X",

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AU - Brown, Thomas M.

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N2 - Selective serotonin reuptake inhibitors (SSRIs) alter peripheral handling of serotonin, leading to potential side effects. Further, the majority of the body's serotonin is found outside the central nervous system. Peripheral serotonin is important in platelet aggregation and the modulation of vascular tone. SSRIs block platelet uptake and pulmonary endothelial metabolism of serotonin, and use of these agents may conceivably result in bleeding and vasospastic complications.

AB - Selective serotonin reuptake inhibitors (SSRIs) alter peripheral handling of serotonin, leading to potential side effects. Further, the majority of the body's serotonin is found outside the central nervous system. Peripheral serotonin is important in platelet aggregation and the modulation of vascular tone. SSRIs block platelet uptake and pulmonary endothelial metabolism of serotonin, and use of these agents may conceivably result in bleeding and vasospastic complications.

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Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors

Abstract

ASJC Scopus subject areas

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