Potential roles of adiponectin isoforms in human obesity with delayedwound healing

Jiyoon Ryu, Colleen A. Loza, Huan Xu, Min Zhou, Jason T. Hadley, Jielei Wu, Huayu You, Huaiqing Wang, Jihong Yang, Juli Bai, Feng Liu, Christie Bialowas, Lily Q. Dong

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Adiponectin is an adipokine with anti-insulin resistance and anti-inflammatory functions. It exists in serum predominantly in three multimeric complexes: the trimer, hexamer, and highmolecular- weight forms. Although recent studies indicate that adiponectin promotes wound healing in rodents, its role in the wound healing process in humans is unknown. This study investigated the expression levels of adiponectin in adipose tissue and serum of women who experienced either normal or delayed wound healing after abdominal plastic surgery. We found that obese women with delayed healing had slightly lower total adiponectin levels in their adipose tissue compared with women with normal healing rates. Among the different isoforms of adiponectin, levels of the trimer forms were significantly reduced in adipose tissue, but not the serum, of obese women with delayed healing compared to women who healed normally. This study provides clinical evidence for a potential role of low-molecular-weight oligomers of adiponectin in the wound healing process as well as implications for an autocrine and/or paracrine mechanism of adiponectin action in adipose tissues.

Original languageEnglish (US)
Article number1134
Issue number10
StatePublished - Oct 2019


  • Adiponectin
  • Human
  • Multimers
  • Woman
  • Wound healing

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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