Potential Role of Adult Hippocampal Neurogenesis in Traumatic Brain Injury

Lucas Alexandre Santos Marzano, Fabyolla Lúcia Macedo de Castro, Caroline Amaral Machado, João Luís Vieira Monteiro de Barros, Thiago Macedo E Cordeiro, Ana Cristina Simões E Silva, Antônio Lúcio Teixeira, Aline Silva de Miranda

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Traumatic brain injury (TBI) is a serious cause of disability and death among young and adult individuals, displaying complex pathophysiology including cellular and molecular mechanisms that are not fully elucidated. Many experimental and clinical studies investigated the potential relationship between TBI and the process by which neurons are formed in the brain, known as neurogenesis. Currently, there are no available treatments for TBI’s long-term consequences being the search for novel therapeutic targets, a goal of highest scientific and clinical priority. Some studies evaluated the benefits of treatments aimed at improving neurogenesis in TBI. In this scenario, herein, we reviewed current pre-clinical studies that evaluated different approaches to improving neurogenesis after TBI while achieving better cognitive outcomes, which may consist in interesting approaches for future treatments.

Original languageEnglish (US)
Pages (from-to)3392-3419
Number of pages28
JournalCurrent Medicinal Chemistry
Volume29
Issue number19
DOIs
StatePublished - Jun 2022
Externally publishedYes

Keywords

  • animal
  • dentate gyrus
  • hippocampus
  • models
  • neurogenesis
  • therapeutics
  • Traumatic brain injury

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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