Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants

Frank Schwarz, Marco Wieland, Zvi Schwartz, Ge Zhao, Frank Rupp, Jürgen Geis-Gerstorfer, Andreas Schedle, Nina Broggini, Michael M. Bornstein, Daniel Buser, Stephen J. Ferguson, Jürgen Becker, Barbara D. Boyan, David L. Cochran

Research output: Contribution to journalReview articlepeer-review

217 Scopus citations


In the past, several modifications of specific surface properties such as topography, structure, chemistry, surface charge, and wettability have been investigated to predictably improve the osseointegration of titanium implants. The aim of the present review was to evaluate, based on the currently available evidence, the impact of hydrophilic surface modifications of titanium for dental implants. A surface treatment was performed to produce hydroxylated/ hydrated titanium surfaces with identical microstructure to either acid-etched, or sand-blasted, large grit and acid-etched substrates, but with hydrophilic character. Preliminary in vitro studies have indicated that the specific properties noted for hydrophilic titanium surfaces have a significant influence on cell differentiation and growth factor production. Animal experiments have pointed out that hydrophilic surfaces improve early stages of soft tissue and hard tissue integration of either nonsubmerged or submerged titanium implants. This data was also corroborated by the results from preliminary clinical studies. In conclusion, the present review has pointed to a potential of hydrophilic surface modifications to support tissue integration of titanium dental implants.

Original languageEnglish (US)
Pages (from-to)544-557
Number of pages14
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Issue number2
StatePublished - Feb 2009


  • Biomechanical testing
  • Histology
  • Hydrophilicity
  • Immunohistochemistry
  • Osteoblast differentiation
  • Surface chemistry
  • Surface energy
  • Titanium implant surfaces

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials


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