TY - JOUR
T1 - Potential Biomarkers of impulsivity in mild traumatic brain injury
T2 - A pilot study
AU - Mlnas Gerais’ Traumatic Brain Injury Study Group
AU - Cardoso, Maíra Glória de Freitas
AU - de Barros, João Luís Vieira Monteiro
AU - de Queiroz, Rafael Alves Bonfim
AU - Rocha, Natalia Pessoa
AU - Silver, Carlisa
AU - da Silva, Agnes Stéphanie
AU - da Silva, Ewelin Wasner Machado
AU - Roque, Isadora Gonçalves
AU - Carvalho, Júlia de Lima
AU - dos Santos, Laura Ferreira
AU - Cota, Letícia Bitencourt
AU - Lemos, Lucas Miranda
AU - Miranda, Mariana Figueiredo
AU - Miranda, Millena Figueiredo
AU - Vianna, Pedro Parenti
AU - Oliveira, Rafael Arantes
AU - de Oliveira Furlam, Tiago
AU - Soares, Túlio Safar Sarquis
AU - Pedroso, Vinicius Sousa Pietra
AU - Faleiro, Rodrigo Moreira
AU - Vieira, Érica Leandro Marciano
AU - Teixeira, Antônio Lúcio
AU - de Souza, Leonardo Cruz
AU - de Miranda, Aline Silva
N1 - Publisher Copyright:
© 2023 Elsevier B.V.
PY - 2023/7/9
Y1 - 2023/7/9
N2 - Very few studies have investigated cognition and impulsivity following mild traumatic brain injury (mTBI) in the general population. Furthermore, the neurobiological mechanisms underlying post-TBI neurobehavioral syndromes are complex and remain to be fully clarified. Herein, we took advantage of machine learning based-modeling to investigate potential biomarkers of mTBI-associated impulsivity. Twenty-one mTBI patients were assessed within one-month post-TBI and their data were compared to 19 healthy controls on measures of impulsivity (Barratt Impulsiveness Scale – BIS), executive functioning, episodic memory, self-report cognitive failures and blood biomarkers of inflammation, vascular and neuronal damage. mTBI patients were significantly more impulsive than controls in BIS total and subscales. Serum levels of sCD40L, Cathepsin D, IL-4, Neuropilin-1, IFN-α2, and Copeptin were associated with impulsivity in mTBI patients. Besides showing that mTBI are associated with impulsivity in non-military people, we unveiled different pathophysiological pathways potentially implicated in mTBI-related impulsivity.
AB - Very few studies have investigated cognition and impulsivity following mild traumatic brain injury (mTBI) in the general population. Furthermore, the neurobiological mechanisms underlying post-TBI neurobehavioral syndromes are complex and remain to be fully clarified. Herein, we took advantage of machine learning based-modeling to investigate potential biomarkers of mTBI-associated impulsivity. Twenty-one mTBI patients were assessed within one-month post-TBI and their data were compared to 19 healthy controls on measures of impulsivity (Barratt Impulsiveness Scale – BIS), executive functioning, episodic memory, self-report cognitive failures and blood biomarkers of inflammation, vascular and neuronal damage. mTBI patients were significantly more impulsive than controls in BIS total and subscales. Serum levels of sCD40L, Cathepsin D, IL-4, Neuropilin-1, IFN-α2, and Copeptin were associated with impulsivity in mTBI patients. Besides showing that mTBI are associated with impulsivity in non-military people, we unveiled different pathophysiological pathways potentially implicated in mTBI-related impulsivity.
KW - Blood biomarkers
KW - Impulsivity
KW - Inhibitory control
KW - Machine Learning
KW - mTBI
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UR - http://www.scopus.com/inward/citedby.url?scp=85158906062&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2023.114457
DO - 10.1016/j.bbr.2023.114457
M3 - Article
C2 - 37116663
AN - SCOPUS:85158906062
SN - 0166-4328
VL - 449
JO - Behavioural Brain Research
JF - Behavioural Brain Research
M1 - 114457
ER -