Potential biological consequences of excessive light exposure

Melatonin suppresion, DNA damage, cancer and neurodegenerative diseases

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This brief review summarizes some of the biological effects of light exposure at an inappropriate time (during the normal dark period) and the potential negative physiological consequences of this light exposure. Two major systems are significantly influenced by light at night. Thus, the circadian system and melatonin synthesis are altered when light is extended into the normal dark period or when the dark period is interrupted by light. This summary reviews the potential sequelae of chronic inappropriate light exposure and the suppression of endogenous melatonin levels. Given that melatonin is a free radical scavenger and antioxidant, conditions that involve free radical damage may be aggravated by light suppression of melatonin levels. The conditions of particular interest for this review are excessive DNA damage (which potentially leads to cancer), cellular destruction in neurodegenerative diseases and aging itself. Further research should be conducted to more accurately define the potential negative impact of light at abnormal times on animal and human pathophysiology.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalNeuroendocrinology Letters
Volume23
Issue numberSUPPL. 2
StatePublished - 2002

Fingerprint

Melatonin
Neurodegenerative Diseases
DNA Damage
Light
Neoplasms
Free Radical Scavengers
Free Radicals
Antioxidants
Research

Keywords

  • Diseases of aging
  • DNA damage
  • Free radical scavenging
  • Light exposure
  • Melatonin suppression
  • Neurodegeneration

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

Cite this

@article{0f4496a3f25b4676bf578a9da0945b67,
title = "Potential biological consequences of excessive light exposure: Melatonin suppresion, DNA damage, cancer and neurodegenerative diseases",
abstract = "This brief review summarizes some of the biological effects of light exposure at an inappropriate time (during the normal dark period) and the potential negative physiological consequences of this light exposure. Two major systems are significantly influenced by light at night. Thus, the circadian system and melatonin synthesis are altered when light is extended into the normal dark period or when the dark period is interrupted by light. This summary reviews the potential sequelae of chronic inappropriate light exposure and the suppression of endogenous melatonin levels. Given that melatonin is a free radical scavenger and antioxidant, conditions that involve free radical damage may be aggravated by light suppression of melatonin levels. The conditions of particular interest for this review are excessive DNA damage (which potentially leads to cancer), cellular destruction in neurodegenerative diseases and aging itself. Further research should be conducted to more accurately define the potential negative impact of light at abnormal times on animal and human pathophysiology.",
keywords = "Diseases of aging, DNA damage, Free radical scavenging, Light exposure, Melatonin suppression, Neurodegeneration",
author = "Reiter, {Russel J}",
year = "2002",
language = "English (US)",
volume = "23",
pages = "9--13",
journal = "Neuroendocrinology Letters",
issn = "0172-780X",
publisher = "Maghira and Maas Publications",
number = "SUPPL. 2",

}

TY - JOUR

T1 - Potential biological consequences of excessive light exposure

T2 - Melatonin suppresion, DNA damage, cancer and neurodegenerative diseases

AU - Reiter, Russel J

PY - 2002

Y1 - 2002

N2 - This brief review summarizes some of the biological effects of light exposure at an inappropriate time (during the normal dark period) and the potential negative physiological consequences of this light exposure. Two major systems are significantly influenced by light at night. Thus, the circadian system and melatonin synthesis are altered when light is extended into the normal dark period or when the dark period is interrupted by light. This summary reviews the potential sequelae of chronic inappropriate light exposure and the suppression of endogenous melatonin levels. Given that melatonin is a free radical scavenger and antioxidant, conditions that involve free radical damage may be aggravated by light suppression of melatonin levels. The conditions of particular interest for this review are excessive DNA damage (which potentially leads to cancer), cellular destruction in neurodegenerative diseases and aging itself. Further research should be conducted to more accurately define the potential negative impact of light at abnormal times on animal and human pathophysiology.

AB - This brief review summarizes some of the biological effects of light exposure at an inappropriate time (during the normal dark period) and the potential negative physiological consequences of this light exposure. Two major systems are significantly influenced by light at night. Thus, the circadian system and melatonin synthesis are altered when light is extended into the normal dark period or when the dark period is interrupted by light. This summary reviews the potential sequelae of chronic inappropriate light exposure and the suppression of endogenous melatonin levels. Given that melatonin is a free radical scavenger and antioxidant, conditions that involve free radical damage may be aggravated by light suppression of melatonin levels. The conditions of particular interest for this review are excessive DNA damage (which potentially leads to cancer), cellular destruction in neurodegenerative diseases and aging itself. Further research should be conducted to more accurately define the potential negative impact of light at abnormal times on animal and human pathophysiology.

KW - Diseases of aging

KW - DNA damage

KW - Free radical scavenging

KW - Light exposure

KW - Melatonin suppression

KW - Neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=0036335878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036335878&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 9

EP - 13

JO - Neuroendocrinology Letters

JF - Neuroendocrinology Letters

SN - 0172-780X

IS - SUPPL. 2

ER -