Potent tumor-initiating activity of the 3,4-Dihydrodiol of 7, 12-Dimethylbenz(a)anthracene in mouse skin

G. L. Gleason, T. J. Slaga

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

The abilities of the racemic trans-3, 4-, 5, 6-, and 8, 9-dihydrodiols of 7, 12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-dimethylbenz-(a)anthracene trans-5, 6- and 8, 9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz(a)anthracene is a proximal carcinogen and that the “bay region” diol-epoxide may be the ultimate carcinogenic form of DMBA.

Original languageEnglish (US)
Pages (from-to)1934-1936
Number of pages3
JournalCancer Research
Volume39
StatePublished - Jun 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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