The abilities of the racemic trans-3, 4-, 5, 6-, and 8, 9-dihydrodiols of 7, 12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-dimethylbenz-(a)anthracene trans-5, 6- and 8, 9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz(a)anthracene is a proximal carcinogen and that the “bay region” diol-epoxide may be the ultimate carcinogenic form of DMBA.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Jun 1 1979|
ASJC Scopus subject areas
- Cancer Research