TY - JOUR
T1 - Potent tumor-initiating activity of the 3,4-Dihydrodiol of 7, 12-Dimethylbenz(a)anthracene in mouse skin
AU - Gleason, G. L.
AU - Slaga, T. J.
PY - 1979/6/1
Y1 - 1979/6/1
N2 - The abilities of the racemic trans-3, 4-, 5, 6-, and 8, 9-dihydrodiols of 7, 12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-dimethylbenz-(a)anthracene trans-5, 6- and 8, 9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz(a)anthracene is a proximal carcinogen and that the “bay region” diol-epoxide may be the ultimate carcinogenic form of DMBA.
AB - The abilities of the racemic trans-3, 4-, 5, 6-, and 8, 9-dihydrodiols of 7, 12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-dimethylbenz-(a)anthracene trans-5, 6- and 8, 9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz(a)anthracene is a proximal carcinogen and that the “bay region” diol-epoxide may be the ultimate carcinogenic form of DMBA.
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M3 - Article
C2 - 109189
AN - SCOPUS:0018757754
VL - 39
SP - 1934
EP - 1936
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
ER -