Abstract
The abilities of the racemic trans-3, 4-, 5, 6-, and 8, 9-dihydrodiols of 7, 12-dimethylbenz(a)anthracene to initiate skin tumors in mice were determined by using a two-stage system of tumorigenesis. The 7,12-dimethylbenz(a)anthracene trans-3,4-dihydrodiol was found to be much more active as a tumor initiator than the parent hydrocarbon. The 7, 12-dimethylbenz-(a)anthracene trans-5, 6- and 8, 9-dihydrodiols were essentially inactive as skin tumor initiators. Our results suggest that the 3, 4-dihydrodiol of 7, 12-dimethylbenz(a)anthracene is a proximal carcinogen and that the “bay region” diol-epoxide may be the ultimate carcinogenic form of DMBA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1934-1936 |
| Number of pages | 3 |
| Journal | Cancer Research |
| Volume | 39 |
| State | Published - Jun 1 1979 |
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ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Gleason, G. L., & Slaga, T. J. (1979). Potent tumor-initiating activity of the 3,4-Dihydrodiol of 7, 12-Dimethylbenz(a)anthracene in mouse skin. Cancer Research, 39, 1934-1936.