Abstract
mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL-severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 10367-10372 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 96 |
| Issue number | 18 |
| DOIs | |
| State | Published - Aug 31 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
- General
Cite this
Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. / Wang, Chang Yi; Sawyer, Lynette S W; Murthy, Krishna K.; Fang, Xinde; Walfield, Alan M.; Ye, John; Wang, James J G; De Chen, Pei; Li, Ming Lie; Salas, Mary T.; Shen, Ming; Gauduin, Marie Claire; Boyle, Rosanne W.; Koup, Richard A.; Montefiori, David C.; Mascola, John R.; Koff, Wayne C.; Hanson, Carl V.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 18, 31.08.1999, p. 10367-10372.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex
AU - Wang, Chang Yi
AU - Sawyer, Lynette S W
AU - Murthy, Krishna K.
AU - Fang, Xinde
AU - Walfield, Alan M.
AU - Ye, John
AU - Wang, James J G
AU - De Chen, Pei
AU - Li, Ming Lie
AU - Salas, Mary T.
AU - Shen, Ming
AU - Gauduin, Marie Claire
AU - Boyle, Rosanne W.
AU - Koup, Richard A.
AU - Montefiori, David C.
AU - Mascola, John R.
AU - Koff, Wayne C.
AU - Hanson, Carl V.
PY - 1999/8/31
Y1 - 1999/8/31
N2 - mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL-severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.
AB - mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL-severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.
UR - http://www.scopus.com/inward/record.url?scp=13044249145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13044249145&partnerID=8YFLogxK
U2 - 10.1073/pnas.96.18.10367
DO - 10.1073/pnas.96.18.10367
M3 - Article
C2 - 10468614
AN - SCOPUS:13044249145
VL - 96
SP - 10367
EP - 10372
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 18
ER -