Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex

Chang Yi Wang; Lynette S.W. Sawyer; Krishna K. Murthy; Xinde Fang; Alan M. Walfield; John Ye; James J.G. Wang; Pei De Chen; Ming Lie Li; Mary T. Salas; Ming Shen; Marie Claire Gauduin; Rosanne W. Boyle; Richard A. Koup; David C. Montefiori; John R. Mascola; Wayne C. Koff; Carl V. Hanson

doi:10.1073/pnas.96.18.10367

Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex

Chang Yi Wang, Lynette S.W. Sawyer, Krishna K. Murthy, Xinde Fang, Alan M. Walfield, John Ye, James J.G. Wang, Pei De Chen, Ming Lie Li, Mary T. Salas, Ming Shen, Marie Claire Gauduin, Rosanne W. Boyle, Richard A. Koup, David C. Montefiori, John R. Mascola, Wayne C. Koff, Carl V. Hanson

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL-severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.

Original language	English (US)
Pages (from-to)	10367-10372
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	96
Issue number	18
DOIs	https://doi.org/10.1073/pnas.96.18.10367
State	Published - Aug 31 1999

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Wang, C. Y., Sawyer, L. S. W., Murthy, K. K., Fang, X., Walfield, A. M., Ye, J., Wang, J. J. G., De Chen, P., Li, M. L., Salas, M. T., Shen, M., Gauduin, M. C., Boyle, R. W., Koup, R. A., Montefiori, D. C., Mascola, J. R., Koff, W. C., & Hanson, C. V. (1999). Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. Proceedings of the National Academy of Sciences of the United States of America, 96(18), 10367-10372. https://doi.org/10.1073/pnas.96.18.10367

Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. / Wang, Chang Yi; Sawyer, Lynette S.W.; Murthy, Krishna K.; Fang, Xinde; Walfield, Alan M.; Ye, John; Wang, James J.G.; De Chen, Pei; Li, Ming Lie; Salas, Mary T.; Shen, Ming; Gauduin, Marie Claire; Boyle, Rosanne W.; Koup, Richard A.; Montefiori, David C.; Mascola, John R.; Koff, Wayne C.; Hanson, Carl V.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 18, 31.08.1999, p. 10367-10372.

Research output: Contribution to journal › Article › peer-review

Wang, CY, Sawyer, LSW, Murthy, KK, Fang, X, Walfield, AM, Ye, J, Wang, JJG, De Chen, P, Li, ML, Salas, MT, Shen, M, Gauduin, MC, Boyle, RW, Koup, RA, Montefiori, DC, Mascola, JR, Koff, WC & Hanson, CV 1999, 'Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, no. 18, pp. 10367-10372. https://doi.org/10.1073/pnas.96.18.10367

Wang, Chang Yi ; Sawyer, Lynette S.W. ; Murthy, Krishna K. ; Fang, Xinde ; Walfield, Alan M. ; Ye, John ; Wang, James J.G. ; De Chen, Pei ; Li, Ming Lie ; Salas, Mary T. ; Shen, Ming ; Gauduin, Marie Claire ; Boyle, Rosanne W. ; Koup, Richard A. ; Montefiori, David C. ; Mascola, John R. ; Koff, Wayne C. ; Hanson, Carl V. / Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 18. pp. 10367-10372.

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abstract = "mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL-severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.",

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