Post-translational modifications of Runx1 regulate its activity in the cell

Lan Wang; Gang Huang; Xinyang Zhao; Megan A. Hatlen; Ly Vu; Fan Liu; Stephen D. Nimer

doi:10.1016/j.bcmd.2009.03.005

Post-translational modifications of Runx1 regulate its activity in the cell

Lan Wang
, Gang Huang
, Xinyang Zhao
, Megan A. Hatlen
, Ly Vu
, Fan Liu
, Stephen D. Nimer

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

Original language	English (US)
Pages (from-to)	30-34
Number of pages	5
Journal	Blood Cells, Molecules, and Diseases
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.bcmd.2009.03.005
State	Published - Jul 2009
Externally published	Yes

Keywords

Acetylation
Acetyltransferases
Leukemia
Methylation
Methyltransferases
Transcription

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Hematology
Cell Biology

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10.1016/j.bcmd.2009.03.005

Cite this

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title = "Post-translational modifications of Runx1 regulate its activity in the cell",

abstract = "In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.",

keywords = "Acetylation, Acetyltransferases, Leukemia, Methylation, Methyltransferases, Transcription",

author = "Lan Wang and Gang Huang and Xinyang Zhao and Hatlen, \{Megan A.\} and Ly Vu and Fan Liu and Nimer, \{Stephen D.\}",

note = "Funding Information: We thank the members of the Nimer lab for helpful discussions. This work was supported by a SCOR grant from the Leukemia Lymphoma Society (SDN). This paper is based on a presentation at the 15th international RUNX workshop sponsored by The Leukemia \& Lymphoma Society in Provincetown, Massachusetts, September 14–17, 2008.",

year = "2009",

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doi = "10.1016/j.bcmd.2009.03.005",

language = "English (US)",

volume = "43",

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journal = "Blood Cells, Molecules, and Diseases",

issn = "1079-9796",

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TY - JOUR

T1 - Post-translational modifications of Runx1 regulate its activity in the cell

AU - Wang, Lan

AU - Huang, Gang

AU - Zhao, Xinyang

AU - Hatlen, Megan A.

AU - Vu, Ly

AU - Liu, Fan

AU - Nimer, Stephen D.

N1 - Funding Information: We thank the members of the Nimer lab for helpful discussions. This work was supported by a SCOR grant from the Leukemia Lymphoma Society (SDN). This paper is based on a presentation at the 15th international RUNX workshop sponsored by The Leukemia & Lymphoma Society in Provincetown, Massachusetts, September 14–17, 2008.

PY - 2009/7

Y1 - 2009/7

N2 - In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

AB - In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.

KW - Acetylation

KW - Acetyltransferases

KW - Leukemia

KW - Methylation

KW - Methyltransferases

KW - Transcription

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UR - https://www.scopus.com/pages/publications/68649116713#tab=citedBy

U2 - 10.1016/j.bcmd.2009.03.005

DO - 10.1016/j.bcmd.2009.03.005

M3 - Review article

C2 - 19386523

AN - SCOPUS:68649116713

SN - 1079-9796

VL - 43

SP - 30

EP - 34

JO - Blood Cells, Molecules, and Diseases

JF - Blood Cells, Molecules, and Diseases

IS - 1

ER -

Post-translational modifications of Runx1 regulate its activity in the cell

Abstract

Keywords

ASJC Scopus subject areas

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