Abstract
In this report we review the current knowledge of the interaction of RUNX1(AML1) with serine/threonine kinases, lysine and arginine methyltransferases, lysine acetyltransferases, and histone deacetylases. We also discuss the effect of RUNX1-ETO fusion gene on DNA methylation. RUNX1 post-transcriptional modification can affect its role in influencing differentiation and self-renewal of hematopoietic cells. The goal of these studies is to develop targets for improved leukemia therapy.
Original language | English (US) |
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Pages (from-to) | 30-34 |
Number of pages | 5 |
Journal | Blood Cells, Molecules, and Diseases |
Volume | 43 |
Issue number | 1 |
DOIs | |
State | Published - Jul 2009 |
Externally published | Yes |
Keywords
- Acetylation
- Acetyltransferases
- Leukemia
- Methylation
- Methyltransferases
- Transcription
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Hematology
- Cell Biology