Post stroke depression: Clinics, etiopathogenesis and therapeutics

Vinicius Sousa Pietra Pedroso, Leonardo Cruz de Souza, Andre R. Brunoni, Antônio Lúcio Teixeira

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Stroke is a major cause of morbidity and mortality worldwide. Neuropsychiatric disorders are often associated with stroke and, among them, depression is the most prevalent. Post-stroke Depression (PSD) is related to disability, failure in returning to work, impairment in interpersonal functioning and mortality. Its etiopathogenesis is still uncertain, as well as its treatment. In Brazil, there are few data on the impact of PSD. Objective: This work is dedicated to conduct a comprehensive review of the concept of PSD, its pathophysiology, morbidity and treatment. Methods: PubMed, Medline and Lilacs searches of relevant terms yielded 3,265 papers in the last 10 years. We selected original studies and reviews that addressed the aspects mentioned above. Results: W e present the history of the notion of PSD and describe its epidemiology, looking to highlight Brazilian studies. Diagnostic criteria and clinical presentation were detailed, with emphasis on cognitive aspects. Te four main pathophysiological theories proposed to PSD are presented and we discuss the various treatment strategies, involving psychopharmacologic options, brain stimulation techniques and psychotherapy. Discussion: This work provides comprehensive information on PSD, of great utility for clinical practice and research in this topic.

Original languageEnglish (US)
Pages (from-to)18-24
Number of pages7
JournalRevista de Psiquiatria Clinica
Issue number1
StatePublished - 2015
Externally publishedYes


  • Cerebrovascular diseases
  • Depression
  • Post-stroke depression
  • Stroke
  • Vascular depression

ASJC Scopus subject areas

  • Psychiatry and Mental health


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