Possible contribution of brain angiotensin III to ingestive behaviors in baboons

J. R. Blair-West, K. D. Carey, D. A. Denton, L. J. Madden, R. S. Weisinger, R. E. Shade

    Research output: Contribution to journalArticlepeer-review

    17 Scopus citations

    Abstract

    Recent experiments with specific aminopeptidase inhibitors in rats have strengthened earlier proposals that ANG III may be an important regulatory peptide in the brain. Central mechanisms regulating blood pressure, ingestive behaviors, and vasopressin release could be involved. Arguments in favor of a role for ANG III depend, in part, on the efficacy of ANG III as an agonist. These first studies in primates tested whether ANG III stimulates ingestive behaviors in baboons. Intracerebroventricular (ICV) infusions of ANG III were as potent as ANG II in stimulating water drinking and intake of NaCl solution. On the basis of this criterion and consistent with findings in rats, ANG III could be a main effector peptide in the regulation of ingestive behaviors in a primate.

    Original languageEnglish (US)
    Pages (from-to)R1633-R1636
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume281
    Issue number5 50-5
    DOIs
    StatePublished - 2001

    Keywords

    • Angiotensin II
    • Intracerebroventricular infusion
    • Sodium intake
    • Water intake

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

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