Positron emission computed tomography and magnetic resonance imaging features of sinonasal small round blue cell tumors

Kerem Ozturk, Mehmet Gencturk, Emiro Caicedo-Granados, Faqian Li, Zuzan Cayci

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Aim: The sinonasal tract hosts numerous types of undifferentiated neoplasms, having small round cell morphology. The aim of this study was to determine whether sinonasal small round blue cell tumors (SRBCT) have distinct imaging features on computed tomography (CT), magnetic resonance imaging (MRI), and 18-fluorodeoxyglucose positron emission tomography (18F-FDG PET)/CT. Methods: Seventy-three patients (43 male; Mage = 61.2 years) with histopathologically proven sinonasal SRBCT were retrospectively reviewed. Imaging features of SRBCTs including location, maximum dimension, margin characteristics, presence of calcification, sclerotic bone changes, intratumoral necrosis, tumor extension, bone destruction, bone remodeling, perineural spread, T1- and T2-weighted MRI signal intensity, qualitative features on diffusion-weighted imaging and 18F-FDG PET/CT, and pattern of contrast enhancement were analyzed using Fisher’s exact test or the chi-square test. The maximum standardized uptake values (SUVmax) and apparent diffusion coefficient (ADCmean) values of SRBCT were compared by utilizing the Kruskal–Wallis test. Results: There was a significant difference between SRBCT type regarding the tumor location (p = 0.006), 18F-FDG uptake pattern (p = 0.006), involvement of the orbit (p = 0.016) and pterygopalatine fossa (p = 0.043), the presence of perineural spread (p < 0.001), bone destruction (p = 0.034), and intratumoral necrosis (p = 0.022). Bone destruction and necrosis were more common in rhabdomyosarcoma. Perineural spread was common in sinonasal adenoid cystic carcinoma (ACC). Qualitative 18F-FDG uptake features as well as tumor location were significantly different between sinonasal ACC and sinonasal undifferentiated carcinoma. The ADCmean and SUVmax values were not statistically different between SRBCT types. Conclusions: Sinonasal SRBCTs have numerous distinct imaging features on CT, MRI, and 18F-FDG PET/CT that could be useful in the differentiation between lesions when the histopathologic diagnosis is inconclusive.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalNeuroradiology Journal
Issue number1
StatePublished - Feb 1 2020
Externally publishedYes


  • 18-fluorodeoxyglucose positron emission tomography scan (F-FDG PET/CT)
  • Sinonasal malignancy
  • diffusion-weighted imaging (DWI)
  • magnetic resonance imaging (MRI)
  • small round blue cell tumor (SRBCT)

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Positron emission computed tomography and magnetic resonance imaging features of sinonasal small round blue cell tumors'. Together they form a unique fingerprint.

Cite this