Positive sharp wave origin: Evidence supporting the electrode initiation hypothesis

Daniel Dumitru, Daniel L. Santa Maria

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented to comprise two distinct populations conforming to relatively short and comparatively longer maximal depolarization times. Those PSWs with short maximal depolarization times were found to be equivalent to end-plate spike maximal depolarization times, whereas those with longer times were comparable to fibrillation potentials. The PSW group with shorter maximal depolarization times was encountered more frequently. The combination of two distinct groups of PSWs with respective times comparable to end-plate spikes and fibrillation potentials supports the hypothesis that the majority of PSWs originate at the recording electrode during insertion, whereas a smaller population of PSWs arises as propagating fibrillation potentials that block at the recording electrode. Subcutaneous compared to intramuscular recordings from denervated muscle document that the recording electrode is necessary to both record and produce PSWs. Hence, this study confirms the proposed hypothesis that the majority of observed PSWs represent a suprathreshold single muscle-fiber discharge induced by, and originating in close proximity to, a perielectrode crushed membrane that then propagate away from the electrode; a smaller population of PSWs conform to that of a blocked fibrillation potential.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalMuscle and Nerve
Volume36
Issue number3
DOIs
StatePublished - Sep 2007

Fingerprint

Electrodes
Action Potentials
Population
Radio Waves
Muscles
Membranes

Keywords

  • End-plate spike
  • Fibrillation potential
  • Needle electromyography
  • Positive sharp wave
  • Single muscle fiber

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Positive sharp wave origin : Evidence supporting the electrode initiation hypothesis. / Dumitru, Daniel; Santa Maria, Daniel L.

In: Muscle and Nerve, Vol. 36, No. 3, 09.2007, p. 349-356.

Research output: Contribution to journalArticle

@article{e536829de6454df7ba158321abacddbf,
title = "Positive sharp wave origin: Evidence supporting the electrode initiation hypothesis",
abstract = "This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented to comprise two distinct populations conforming to relatively short and comparatively longer maximal depolarization times. Those PSWs with short maximal depolarization times were found to be equivalent to end-plate spike maximal depolarization times, whereas those with longer times were comparable to fibrillation potentials. The PSW group with shorter maximal depolarization times was encountered more frequently. The combination of two distinct groups of PSWs with respective times comparable to end-plate spikes and fibrillation potentials supports the hypothesis that the majority of PSWs originate at the recording electrode during insertion, whereas a smaller population of PSWs arises as propagating fibrillation potentials that block at the recording electrode. Subcutaneous compared to intramuscular recordings from denervated muscle document that the recording electrode is necessary to both record and produce PSWs. Hence, this study confirms the proposed hypothesis that the majority of observed PSWs represent a suprathreshold single muscle-fiber discharge induced by, and originating in close proximity to, a perielectrode crushed membrane that then propagate away from the electrode; a smaller population of PSWs conform to that of a blocked fibrillation potential.",
keywords = "End-plate spike, Fibrillation potential, Needle electromyography, Positive sharp wave, Single muscle fiber",
author = "Daniel Dumitru and {Santa Maria}, {Daniel L.}",
year = "2007",
month = "9",
doi = "10.1002/mus.20819",
language = "English (US)",
volume = "36",
pages = "349--356",
journal = "Muscle and Nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Positive sharp wave origin

T2 - Evidence supporting the electrode initiation hypothesis

AU - Dumitru, Daniel

AU - Santa Maria, Daniel L.

PY - 2007/9

Y1 - 2007/9

N2 - This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented to comprise two distinct populations conforming to relatively short and comparatively longer maximal depolarization times. Those PSWs with short maximal depolarization times were found to be equivalent to end-plate spike maximal depolarization times, whereas those with longer times were comparable to fibrillation potentials. The PSW group with shorter maximal depolarization times was encountered more frequently. The combination of two distinct groups of PSWs with respective times comparable to end-plate spikes and fibrillation potentials supports the hypothesis that the majority of PSWs originate at the recording electrode during insertion, whereas a smaller population of PSWs arises as propagating fibrillation potentials that block at the recording electrode. Subcutaneous compared to intramuscular recordings from denervated muscle document that the recording electrode is necessary to both record and produce PSWs. Hence, this study confirms the proposed hypothesis that the majority of observed PSWs represent a suprathreshold single muscle-fiber discharge induced by, and originating in close proximity to, a perielectrode crushed membrane that then propagate away from the electrode; a smaller population of PSWs conform to that of a blocked fibrillation potential.

AB - This investigation analyzes the temporal characteristics of maximal depolarization times for three waveforms: end-plate spikes, fibrillation potentials, and positive sharp waves (PSWs) to provide support for the electrode initiation hypothesis of PSW induction. The maximal depolarization times for PSWs are documented to comprise two distinct populations conforming to relatively short and comparatively longer maximal depolarization times. Those PSWs with short maximal depolarization times were found to be equivalent to end-plate spike maximal depolarization times, whereas those with longer times were comparable to fibrillation potentials. The PSW group with shorter maximal depolarization times was encountered more frequently. The combination of two distinct groups of PSWs with respective times comparable to end-plate spikes and fibrillation potentials supports the hypothesis that the majority of PSWs originate at the recording electrode during insertion, whereas a smaller population of PSWs arises as propagating fibrillation potentials that block at the recording electrode. Subcutaneous compared to intramuscular recordings from denervated muscle document that the recording electrode is necessary to both record and produce PSWs. Hence, this study confirms the proposed hypothesis that the majority of observed PSWs represent a suprathreshold single muscle-fiber discharge induced by, and originating in close proximity to, a perielectrode crushed membrane that then propagate away from the electrode; a smaller population of PSWs conform to that of a blocked fibrillation potential.

KW - End-plate spike

KW - Fibrillation potential

KW - Needle electromyography

KW - Positive sharp wave

KW - Single muscle fiber

UR - http://www.scopus.com/inward/record.url?scp=34548258862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548258862&partnerID=8YFLogxK

U2 - 10.1002/mus.20819

DO - 10.1002/mus.20819

M3 - Article

C2 - 17487870

AN - SCOPUS:34548258862

VL - 36

SP - 349

EP - 356

JO - Muscle and Nerve

JF - Muscle and Nerve

SN - 0148-639X

IS - 3

ER -