Positive sharp wave and fibrillation potential modeling

Daniel Dumitru, John C. King, William E. Rogers, Dick F. Stegeman

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A finite muscle fiber simulation program which calculates the extracellular potential for any given intracellular action potential (IAP) was used to model a fibrillation potential and a positive sharp wave. This computer model employs the core conductor model assumptions for an active muscle fiber and allows two distinct types of end effects: a cut or a crush. A 'cut end' is defined as a membrane segment with the termination of both active and passive ion channels. The 'crush end' is simulated as a focal membrane segment which blocks action potential propagation, and is connected to a region of normal membrane on either side of it so that a normal transmembrane potential is maintained beyond the crush zone. A prototypical positive sharp wave of appropriate amplitude and duration could only be detected extracellularly by using an IAP of the configuration found in denervated rat muscle recorded from a muscle fiber terminating in a crush segment of membrane.

Original languageEnglish (US)
Pages (from-to)242-251
Number of pages10
JournalMuscle and Nerve
Volume22
Issue number2
DOIs
StatePublished - Feb 15 1999

Keywords

  • Action potential
  • Fibrillation potential
  • Positive sharp wave
  • Single muscle fiber
  • Volume conduction

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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