Portable oral cancer detection using a miniature confocal imaging probe with a large field of view

Youmin Wang, Milan Raj, H. Stan McGuff, Gauri Bhave, Bin Yang, Ting Shen, Xiaojing Zhang

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We demonstrate a MEMS micromirror enabled handheld confocal imaging probe for portable oral cancer detection, where a comparatively large field of view (FOV) was generated through the programmable Lissajous scanning pattern of the MEMS micromirror. Miniaturized handheld MEMS confocal imaging probe was developed, and further compared with the desktop confocal prototype under clinical setting. For the handheld confocal imaging system, optical design simulations using CODE V Rshows the lateral and axial resolution to be 0.98νm and 4.2 νm, where experimental values were determined to be 3 νm and 5.8 νm, respectively, with a FOV of 280 νm×300 νm. Fast Lissajous imaging speed up to 2 fps was realized with improved Labview and Java based real-time imaging software. Properties such as 3D imaging through autofocusing and mosaic imaging for extended lateral view (6mm×8mm) were examined for carcinoma real-time pathology. Neoplastic lesion tissues of giant cell fibroma and peripheral ossifying fibroma, the fibroma inside the paraffin box and ex vivo gross tissues were imaged by the bench-top and handheld imaging modalities, and further compared with commercial microscope imaging results. The MEMS scanner-based handheld confocal imaging probe shows great promise as a potential clinical tool for oral cancer diagnosis and treatment.

Original languageEnglish (US)
Article number065001
JournalJournal of Micromechanics and Microengineering
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2012

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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