Porous-coated titanium implant impregnated with a biodegradable protein delivery system

C. M. Agrawal, A. Pennick, X. Wang, R. C. Schenck

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Tissue ingrowth into porous-coated orthopedic and dental implants is commonly used as a means to achieve long-term fixation of these prostheses. However, the degree of tissue ingrowth is often inadequate and inconsistent. If the pores of these implants are impregnated with a controlled drug release system delivering relevant growth factors, then it might be possible to stimulate more tissue ingrowth. The present study introduces such a system based on biodegradable polymers and investigates its protein release profile and polymer degradation characteristics. Porous coated titanium implants were impregnated with a mixture of a 50%-50% polylactic acid-polyglycolic acid copolymer and a model protein, soybean trypsin inhibitor. Control implants contained only the polymer and no protein. The implants were subjected to hydrolyric degradation in phosphate buffered saline at 37°C for periods of 3, 6, and 11 weeks. The protein release and the mass and molecular weight of the polymer were monitored. The results indicate that the protein is released in three distinct phases and the polymer loses almost all its mass and molecular weight by 11 weeks. There was a significant difference in the polymer degradation characteristics between the control and test implants, which might be the result of some complex polymer-protein interactions.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalJournal of Biomedical Materials Research
Volume36
Issue number4
DOIs
StatePublished - Sep 15 1997

Fingerprint

Titanium
Polymers
Proteins
Tissue
Degradation
Molecular weight
Molecular Weight
Prosthesis Retention
Dental prostheses
Soybean Proteins
Biodegradable polymers
Trypsin Inhibitors
Acids
Orthopedics
Prosthetics
Dental Implants
Intercellular Signaling Peptides and Proteins
Phosphates
Copolymers
Pharmaceutical Preparations

Keywords

  • Degradation
  • PLA-PGA
  • Porous-coated
  • Protein release
  • Titanium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Porous-coated titanium implant impregnated with a biodegradable protein delivery system. / Agrawal, C. M.; Pennick, A.; Wang, X.; Schenck, R. C.

In: Journal of Biomedical Materials Research, Vol. 36, No. 4, 15.09.1997, p. 516-521.

Research output: Contribution to journalArticle

Agrawal, C. M. ; Pennick, A. ; Wang, X. ; Schenck, R. C. / Porous-coated titanium implant impregnated with a biodegradable protein delivery system. In: Journal of Biomedical Materials Research. 1997 ; Vol. 36, No. 4. pp. 516-521.
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