Abstract
Tissue ingrowth into porous-coated orthopedic and dental implants is commonly used as a means to achieve long-term fixation of these prostheses. However, the degree of tissue ingrowth is often inadequate and inconsistent. If the pores of these implants are impregnated with a controlled drug release system delivering relevant growth factors, then it might be possible to stimulate more tissue ingrowth. The present study introduces such a system based on biodegradable polymers and investigates its protein release profile and polymer degradation characteristics. Porous coated titanium implants were impregnated with a mixture of a 50%-50% polylactic acid-polyglycolic acid copolymer and a model protein, soybean trypsin inhibitor. Control implants contained only the polymer and no protein. The implants were subjected to hydrolyric degradation in phosphate buffered saline at 37°C for periods of 3, 6, and 11 weeks. The protein release and the mass and molecular weight of the polymer were monitored. The results indicate that the protein is released in three distinct phases and the polymer loses almost all its mass and molecular weight by 11 weeks. There was a significant difference in the polymer degradation characteristics between the control and test implants, which might be the result of some complex polymer-protein interactions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 516-521 |
| Number of pages | 6 |
| Journal | Journal of Biomedical Materials Research |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| State | Published - Sep 15 1997 |
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Keywords
- Degradation
- PLA-PGA
- Porous-coated
- Protein release
- Titanium
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
Cite this
Porous-coated titanium implant impregnated with a biodegradable protein delivery system. / Agrawal, C. M.; Pennick, A.; Wang, X.; Schenck, R. C.
In: Journal of Biomedical Materials Research, Vol. 36, No. 4, 15.09.1997, p. 516-521.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Porous-coated titanium implant impregnated with a biodegradable protein delivery system
AU - Agrawal, C. M.
AU - Pennick, A.
AU - Wang, X.
AU - Schenck, R. C.
PY - 1997/9/15
Y1 - 1997/9/15
N2 - Tissue ingrowth into porous-coated orthopedic and dental implants is commonly used as a means to achieve long-term fixation of these prostheses. However, the degree of tissue ingrowth is often inadequate and inconsistent. If the pores of these implants are impregnated with a controlled drug release system delivering relevant growth factors, then it might be possible to stimulate more tissue ingrowth. The present study introduces such a system based on biodegradable polymers and investigates its protein release profile and polymer degradation characteristics. Porous coated titanium implants were impregnated with a mixture of a 50%-50% polylactic acid-polyglycolic acid copolymer and a model protein, soybean trypsin inhibitor. Control implants contained only the polymer and no protein. The implants were subjected to hydrolyric degradation in phosphate buffered saline at 37°C for periods of 3, 6, and 11 weeks. The protein release and the mass and molecular weight of the polymer were monitored. The results indicate that the protein is released in three distinct phases and the polymer loses almost all its mass and molecular weight by 11 weeks. There was a significant difference in the polymer degradation characteristics between the control and test implants, which might be the result of some complex polymer-protein interactions.
AB - Tissue ingrowth into porous-coated orthopedic and dental implants is commonly used as a means to achieve long-term fixation of these prostheses. However, the degree of tissue ingrowth is often inadequate and inconsistent. If the pores of these implants are impregnated with a controlled drug release system delivering relevant growth factors, then it might be possible to stimulate more tissue ingrowth. The present study introduces such a system based on biodegradable polymers and investigates its protein release profile and polymer degradation characteristics. Porous coated titanium implants were impregnated with a mixture of a 50%-50% polylactic acid-polyglycolic acid copolymer and a model protein, soybean trypsin inhibitor. Control implants contained only the polymer and no protein. The implants were subjected to hydrolyric degradation in phosphate buffered saline at 37°C for periods of 3, 6, and 11 weeks. The protein release and the mass and molecular weight of the polymer were monitored. The results indicate that the protein is released in three distinct phases and the polymer loses almost all its mass and molecular weight by 11 weeks. There was a significant difference in the polymer degradation characteristics between the control and test implants, which might be the result of some complex polymer-protein interactions.
KW - Degradation
KW - PLA-PGA
KW - Porous-coated
KW - Protein release
KW - Titanium
UR - http://www.scopus.com/inward/record.url?scp=9844227908&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=9844227908&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-4636(19970915)36:4<516::AID-JBM9>3.0.CO;2-H
DO - 10.1002/(SICI)1097-4636(19970915)36:4<516::AID-JBM9>3.0.CO;2-H
M3 - Article
C2 - 9294767
AN - SCOPUS:9844227908
VL - 36
SP - 516
EP - 521
JO - Journal of Biomedical Materials Research - Part A
JF - Journal of Biomedical Materials Research - Part A
SN - 0021-9304
IS - 4
ER -