Porcine von Willebrand disease and atherosclerosis: Influence of polymorphism in apolipoprotein B100 genotype

T. C. Nichols, D. A. Bellinger, K. E. Davis, G. G. Koch, R. L. Reddick, M. S. Read, J. Rapacz, J. Hasler-Rapacz, K. M. Brinkhous, T. R. Griggs

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The relationship of apolipoprotein-B genotype (Lpb) to diet-induced hypercholesterolemia and atherosclerosis was studied in von Willebrand disease (vWD) and normal pigs. Von Willebrand and normal pigs developed comparable levels of hypercholesterolemia (respectively, 757.9 ± 49.4 versus 772.8 ± 47.9 mg/dl, P = 0.95). Pigs with Lpb1/5 and Lpb5/8 genotypes, however, developed significantly higher serum cholesterol levels than those with other Lpb genotypes (866.1 ± 64.0 mg/dl, P = 0.0343). Coronary and aortic atherosclerosis, measured by computer-assisted automated image analyzer, were not significantly different between vWD and normal pigs. Pigs with an Lpb5 allele developed significantly more atherosclerosis than those with the Lpb3/8 or Lpb8/8 genotypes or the rare Lpb1 allele (r ≥ 0.434, P ≤ 0.05). Polymorphism in apolipoprotein B100 genotype, then, significantly influenced the severity of diet-induced hypercholesterolemia and atherosclerotic plaque formation in vWD and normal swine without regard to the vWD genotype.

Original languageEnglish (US)
Pages (from-to)403-415
Number of pages13
JournalAmerican Journal of Pathology
Volume140
Issue number2
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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