Population pharmacokinetics of racemic warfarin in adult patients

D. R. Mungall, T. M. Ludden, J. Marshall, D. W. Hawkins, Robert Talbert, M. H. Crawford

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

The population pharmacokinetics of racemic warfarin was evaluated using 613 measured warfarin plasma concentrations from 32 adult hospitalized patients and 131 adult outpatients. Warfarin concentrations were measured in duplicate using a high-performance liquid chromatographic procedure. The pharmacokinetic model used was a one-compartment open model with first-order absorption (absorption rate constant set equal to 47 day-1) and first-order elimination. The extent of availability was assumed to be one. A linear regression model was used to evaluate the influence of various demographic factors on warfarin oral clearance. Age appeared to be an important determinant of warfarin clearance in this adult population. There was about a 1%/year decrease in oral clearance over the age range of 20-70 years. Smoking appeared to result in a 10% increase in warfarin clearance, while coadministration of the inducers phenytoin or phenobarbital yielded about a 30% increase in clearance. This study has yielded a predictive model that, when combined with appropriate pharmacological response data, may be useful in the design and adjustment of warfarin regimens.

Original languageEnglish (US)
Pages (from-to)213-227
Number of pages15
JournalJournal of Pharmacokinetics and Biopharmaceutics
Volume13
Issue number3
DOIs
StatePublished - Jun 1985

Fingerprint

Warfarin
Pharmacokinetics
Population
Linear Models
Social Adjustment
Phenytoin
Phenobarbital
Outpatients
Smoking
Demography
Pharmacology

Keywords

  • age and kinetics
  • anticoagulants
  • population analysis
  • warfarin kinetics

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

Mungall, D. R., Ludden, T. M., Marshall, J., Hawkins, D. W., Talbert, R., & Crawford, M. H. (1985). Population pharmacokinetics of racemic warfarin in adult patients. Journal of Pharmacokinetics and Biopharmaceutics, 13(3), 213-227. https://doi.org/10.1007/BF01065653

Population pharmacokinetics of racemic warfarin in adult patients. / Mungall, D. R.; Ludden, T. M.; Marshall, J.; Hawkins, D. W.; Talbert, Robert; Crawford, M. H.

In: Journal of Pharmacokinetics and Biopharmaceutics, Vol. 13, No. 3, 06.1985, p. 213-227.

Research output: Contribution to journalArticle

Mungall, DR, Ludden, TM, Marshall, J, Hawkins, DW, Talbert, R & Crawford, MH 1985, 'Population pharmacokinetics of racemic warfarin in adult patients', Journal of Pharmacokinetics and Biopharmaceutics, vol. 13, no. 3, pp. 213-227. https://doi.org/10.1007/BF01065653
Mungall DR, Ludden TM, Marshall J, Hawkins DW, Talbert R, Crawford MH. Population pharmacokinetics of racemic warfarin in adult patients. Journal of Pharmacokinetics and Biopharmaceutics. 1985 Jun;13(3):213-227. https://doi.org/10.1007/BF01065653
Mungall, D. R. ; Ludden, T. M. ; Marshall, J. ; Hawkins, D. W. ; Talbert, Robert ; Crawford, M. H. / Population pharmacokinetics of racemic warfarin in adult patients. In: Journal of Pharmacokinetics and Biopharmaceutics. 1985 ; Vol. 13, No. 3. pp. 213-227.
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