Poor perinatal growth impairs baboon aortic windkessel function

A. H. Kuo, J. Li, C. Li, H. F. Huber, P. W. Nathanielsz, Geoffrey D Clarke

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The ability of the aorta to buffer blood flow and provide diastolic perfusion (Windkessel function) is a determinant of cardiovascular health. We have reported cardiac dysfunction indicating downstream vascular abnormalities in young adult baboons who were intrauterine growth restricted (IUGR) at birth as a result of moderate maternal nutrient reduction. Using 3 T MRI, we examined IUGR offspring (eight male, eight female; 5.7 years; human equivalent 25 years) and age-matched controls (eight male, eight female; 5.6 years) to quantify distal descending aortic cross-section (AC) and distensibility (AD). ANOVA showed decreased IUGR AC/body surface area (0.9±0.05 cm2/m2 v. 1.2±0.06 cm2/m2, M±s.e.m., P<0.005) and AD (1.7±0.2 v. 4.0±0.5×10-3/mmHg, P<0.005) without sex difference or group-sex interaction, suggesting intrinsic vascular pathology and impaired development persisting in adulthood. Future studies should evaluate potential consequences of these changes on coronary perfusion, afterload and blood pressure.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalJournal of Developmental Origins of Health and Disease
Volume9
Issue number2
DOIs
StatePublished - Apr 1 2018

Keywords

  • aorta
  • baboons
  • developmental programing
  • intrauterine growth restriction
  • maternal nutrient restriction

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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