Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype

F. DeKeyser; H. DeKeyser; M. D. Kazatchkine; F. Rossi; H. Dang; N. Talal

Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype

F. DeKeyser, H. DeKeyser, M. D. Kazatchkine, F. Rossi, H. Dang, N. Talal

Developmental Dentistry

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23 Scopus citations

Abstract

Objective: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). Methods: ELISA were used to determine anti-idiotype antibody activity in IVIG. Results: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotpic binding activity was predominately directed against the 4B4 V(H) region. Conclusion: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab(2β) type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.

Original language	English (US)
Pages (from-to)	587-591
Number of pages	5
Journal	Clinical and Experimental Rheumatology
Volume	14
Issue number	6
State	Published - Nov 1996

Keywords

Sm nucleoprotein
idiotype
systemic lupus erythematosus

ASJC Scopus subject areas

Rheumatology
Immunology and Allergy
Immunology

Cite this

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title = "Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype",

abstract = "Objective: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). Methods: ELISA were used to determine anti-idiotype antibody activity in IVIG. Results: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotpic binding activity was predominately directed against the 4B4 V(H) region. Conclusion: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab(2β) type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.",

keywords = "Sm nucleoprotein, idiotype, systemic lupus erythematosus",

author = "F. DeKeyser and H. DeKeyser and Kazatchkine, {M. D.} and F. Rossi and H. Dang and N. Talal",

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language = "English (US)",

volume = "14",

pages = "587--591",

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TY - JOUR

T1 - Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype

AU - DeKeyser, F.

AU - DeKeyser, H.

AU - Kazatchkine, M. D.

AU - Rossi, F.

AU - Dang, H.

AU - Talal, N.

PY - 1996/11

Y1 - 1996/11

N2 - Objective: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). Methods: ELISA were used to determine anti-idiotype antibody activity in IVIG. Results: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotpic binding activity was predominately directed against the 4B4 V(H) region. Conclusion: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab(2β) type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.

AB - Objective: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). Methods: ELISA were used to determine anti-idiotype antibody activity in IVIG. Results: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotpic binding activity was predominately directed against the 4B4 V(H) region. Conclusion: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab(2β) type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.

KW - Sm nucleoprotein

KW - idiotype

KW - systemic lupus erythematosus

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Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype

Abstract

Keywords

ASJC Scopus subject areas

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