Abstract
Objective: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). Methods: ELISA were used to determine anti-idiotype antibody activity in IVIG. Results: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotpic binding activity was predominately directed against the 4B4 V(H) region. Conclusion: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab(2β) type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 587-591 |
| Number of pages | 5 |
| Journal | Clinical and Experimental Rheumatology |
| Volume | 14 |
| Issue number | 6 |
| State | Published - Nov 1996 |
Keywords
- Sm nucleoprotein
- idiotype
- systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology
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DeKeyser, F., DeKeyser, H., Kazatchkine, M. D., Rossi, F., Dang, H., & Talal, N. (1996). Pooled human immunoglobulins contain anti-idiotypes with reactivity against the SLE-associated 4B4 cross-reactive idiotype. Clinical and Experimental Rheumatology, 14(6), 587-591.