Abstract
Objective: To identify anti-idiotype antibody activity against a regulatory anti-Sm idiotype (4B4) in pooled human IgG (IVIG). Methods: ELISA were used to determine anti-idiotype antibody activity in IVIG. Results: Anti-idiotype antibody activity to 4B4 was detected in IVIG. The anti-idiotypic activity in IVIG could be inhibited by antigen, Sm, and rabbit anti-idiotypic antiserum. The idiotpic binding activity was predominately directed against the 4B4 V(H) region. Conclusion: IVIG contains antibodies against a lupus-associated crossreactive idiotype. These antibodies represent Ab(2β) type antibodies. The anti-idiotypic activity in IVIG may be relevant to the efficacious use of IVIG in treating rheumatic diseases.
Original language | English (US) |
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Pages (from-to) | 587-591 |
Number of pages | 5 |
Journal | Clinical and Experimental Rheumatology |
Volume | 14 |
Issue number | 6 |
State | Published - Nov 1996 |
Keywords
- Sm nucleoprotein
- idiotype
- systemic lupus erythematosus
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology