Polyostotic fibrous dysplasia in a cynomolgus macaque (Macaca fascicularis)

Cassondra Bauer, Betty G. Dunn, Arthur R. Brothman, Edward J. Dick, Chris Christensen, Andra Voges, Charleen M. Moore

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A 2.3-y-old female cynomolgus macaque (Macaca fascicularis) presented with a broken right tibia and fibula. Radiographs showed multiple cyst-like defects in all long bones. We suspected that both fractures were pathologic because they occurred through these defects. Ultrasonography, MRI, and dual X-ray absorptiometry revealed that the defects were filled with soft tissue. Grossly, the bones were abnormal in shape, and a gelatinous material filled the defects and the surrounding marrow cavity. Histologically, the gelatinous material was composed of fibrin and cartilage; few normal bone cells were seen. Genetic testing revealed extra material on the short arm of chromosome 8 in all tissues examined, but no copy number alterations of likely clinical significance were observed, and no abnormalities were found that were unique to the lesions. In light of the clinical signs and radiographic and pathologic findings, polyostotic fibrous dysplasia was diagnosed. This report represents the first documented case of fibrous dysplasia in a cynomolgus macaque.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalComparative medicine
Volume62
Issue number2
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

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    Bauer, C., Dunn, B. G., Brothman, A. R., Dick, E. J., Christensen, C., Voges, A., & Moore, C. M. (2012). Polyostotic fibrous dysplasia in a cynomolgus macaque (Macaca fascicularis). Comparative medicine, 62(2), 142-148.