Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer susceptibility

Joanne E. Curran, Stephen R. Weinstein, Lyn R. Griffiths

    Research output: Contribution to journalArticle

    73 Scopus citations

    Abstract

    The glutathione S-transferase (GST) family of enzymes function in the body to detoxify carcinogenic compounds. Several genes that code for these enzymes are polymorphic, with particular genotypes previously shown to confer an increased cancer risk. In this study, we investigated the role of three GST genes (GSTM1, GSTP1 and GSTT1) in the development of sporadic breast cancer. Genotypes were determined in 129 breast cancer affected and 129 age and sex matched control individuals. Results did not support an involvement of these specific GST gene polymorphisms, either independently or in combination, in susceptibility to sporadic breast cancer in the tested Australian Caucasian population. Copyright (C) 2000 Published by Elsevier Science Ireland Ltd.

    Original languageEnglish (US)
    Pages (from-to)113-120
    Number of pages8
    JournalCancer Letters
    Volume153
    Issue number1-2
    DOIs
    StatePublished - May 29 2000

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    Keywords

    • Glutathione S-transferases
    • Polymorphism
    • Sporadic breast cancer
    • Susceptibility

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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