Polymorphisms identification and associations of KLF7 gene with cattle growth traits

L. Ma, Y. J. Qu, Y. T. Huai, Z. J. Li, J. Wang, X. Y. Lan, C. L. Zhang, J. Q. Wang, H. Chen

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The Kruppel-like factor KLF7 gene was studied as a candidate for genetic markers of growth traits. We investigated the growth traits at different ages of 1002 Chinese cattles belonging to four breeds and applied artificially created restriction site (ACRS)-PCR-RFLP and DNA sequencing methods to reveal three SNPs: NC_007300:g.41401C>T (p.F54F), 42025T>C and 42075A>G. The statistical results indicated there was a strong linkage not only between C41401T and T42025C in Jiaxian, but also between T42025C and A42075G in Qinchuan, Nanyang and Chinese Holstein respectively (r2>0.33). Significant statistical differences in genotypic frequencies at the three loci displayed that the polymorphisms were remarkably correlated with cattle breeds by Χ2 test (P<0.001). In addition, the cattle with genotype T2T2, C2C2 (T42025C), A3A3 (A42075G), haplotype C1C1C2C2A3A3 and C1T1T2C2A3G3 showed better growth traits (P<0.01). The biochemical and physiological functions, together with the results obtained in our investigation, suggest that the KLF7 gene might play important roles affecting growth traits in cattle.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalLivestock Science
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • Cattle
  • Growth traits
  • KLF7 gene
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Animal Science and Zoology
  • General Veterinary


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