Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer

Joanne E. Curran, Stephen R. Weinstein, Lyn R. Griffiths

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Nuclear factor kappa-beta (NF-κB) is a transcription factor responsible for modulating the expression of many genes involved in cell proliferation, differentiation, apoptosis and metastasis. NF-κB interacts with IκB inhibitory proteins to regulate gene expression. This study investigated common variants within the genes coding for NF-κB and IκB, NFKB1 and NFKBIA, for involvement in sporadic breast cancer. Genotypes were determined in a population of breast cancer affected individuals and age-matched controls. Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population.

Original languageEnglish (US)
Pages (from-to)103-107
Number of pages5
JournalCancer Letters
Volume188
Issue number1-2
DOIs
StatePublished - Dec 15 2002
Externally publishedYes

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Breast Neoplasms
Gene Expression
Proteins
Population
Cell Differentiation
Transcription Factors
Genotype
Cell Proliferation
Apoptosis
Neoplasm Metastasis
Genes

Keywords

  • NFKB1
  • NFKBIA
  • Polymorphism
  • Sporadic breast cancer

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. / Curran, Joanne E.; Weinstein, Stephen R.; Griffiths, Lyn R.

In: Cancer Letters, Vol. 188, No. 1-2, 15.12.2002, p. 103-107.

Research output: Contribution to journalArticle

Curran, Joanne E. ; Weinstein, Stephen R. ; Griffiths, Lyn R. / Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer. In: Cancer Letters. 2002 ; Vol. 188, No. 1-2. pp. 103-107.
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