Polymorphic variants of NFKB1 and its inhibitory protein NFKBIA, and their involvement in sporadic breast cancer

Joanne E. Curran, Stephen R. Weinstein, Lyn R. Griffiths

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    Abstract

    Nuclear factor kappa-beta (NF-κB) is a transcription factor responsible for modulating the expression of many genes involved in cell proliferation, differentiation, apoptosis and metastasis. NF-κB interacts with IκB inhibitory proteins to regulate gene expression. This study investigated common variants within the genes coding for NF-κB and IκB, NFKB1 and NFKBIA, for involvement in sporadic breast cancer. Genotypes were determined in a population of breast cancer affected individuals and age-matched controls. Results do not support an involvement of the tested NFKB1 and NFKBIA polymorphisms in susceptibility to sporadic breast cancer, in the tested Caucasian population.

    Original languageEnglish (US)
    Pages (from-to)103-107
    Number of pages5
    JournalCancer Letters
    Volume188
    Issue number1-2
    DOIs
    StatePublished - Dec 15 2002

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    Keywords

    • NFKB1
    • NFKBIA
    • Polymorphism
    • Sporadic breast cancer

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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