Polymeric Iron Chelator with Enhanced Iron Affinity as a Broad-Spectrum Antifungal Agent

Jian Qian, Nathan P. Wiederhold, Thomas Patterson, Hoja Patterson, Cory J. Berkland

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Developing broad-spectrum antifungal drugs represents a pressing need for reducing the global burden of fungal infections. We took advantage of the conformational stability effect to develop a high-avidity polymeric iron chelator, 2,3-dihydroxybenzoic acid-conjugated poly(l-lysine hydrochloride) (PLL-DHBA), which exhibited a stronger iron affinity than typical siderophores produced by fungi. Minimum inhibitory concentration studies against 8 types of fungi including 37 strains showed that the PLL-DHBA iron chelator exhibited a broad-spectrum antifungal effect. Moreover, PLL-DHBA was even more potent than some traditional antifungal drugs for certain drug-resistant fungi.

Original languageEnglish (US)
Pages (from-to)6034-6039
Number of pages6
JournalACS Applied Polymer Materials
Volume3
Issue number12
DOIs
StatePublished - Dec 10 2021

Keywords

  • antifungal drug
  • broad-spectrum antifungal effect
  • polymeric iron chelator
  • reductive iron assimilation
  • siderophore

ASJC Scopus subject areas

  • Polymers and Plastics
  • Process Chemistry and Technology
  • Organic Chemistry

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