Polyhydroxy compounds and thermotolerance: A proposed concatenation

K. J. Henle, W. A. Nagle, A. J. Moss, T. S. Herman

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The polyol hypothesis for cellular thermotolerance development (1) represents a mechanism by which cells could increase their thermal resistance; (2) is supported, in concept, by the limited amount of data currently available; (3) suggests specific relationships that can be experimentally tested. Data obtained from the specific experiments suggested should clarify the relationship of pyridine, glutathione, and carbohydrate metabolism with the phenomenon of thermotolerance.

Original languageEnglish (US)
Pages (from-to)445-451
Number of pages7
JournalRadiation Research
Issue number3
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Radiation
  • Radiology Nuclear Medicine and imaging


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