Polygraphic sleep measures differentiate alcoholics and stimulant abusers during short-term abstinence

Peter M. Thompson; J. Christian Gillin; Shahrokh Golshan; Michael Irwin

doi:10.1016/0006-3223(95)00070-4

Polygraphic sleep measures differentiate alcoholics and stimulant abusers during short-term abstinence

Peter M. Thompson, J. Christian Gillin, Shahrokh Golshan, Michael Irwin

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

We hypothesized that stimulant abusers would sleep more and have more rapid eye movement (REM) sleep than primary alcoholics during acute withdrawal (first 10 days drug free) but would have opposite patterns during subacute withdrawal (days 11-14 drug free). We compared polygraphic sleep patterns during acute withdrawal (days 3-10) for 7 stimulant abusers and 8 alcoholics and during subacute withdrawal (days 11-14) for 7 different stimulant abusers and 8 different alcoholics. For comparison purposes, a group of normal controls from our preexisting database were matched for age and gender. Two statistically significant interactions were found: consistent with our hypothesis, stimulant abusers showed greater total sleep (TST) and REM sleep during acute withdrawal than subacute withdrawal, compared with alcoholics. In contrast, alcoholics showed less TST and REM sleep during acute withdrawal than during subacute withdrawal. Our polygraphic sleep data support the hypothesis that physiological withdrawal differs in alcoholics compared with stimulant abusers. Different mechanisms may underlie withdrawal in these two substances.

Original language	English (US)
Pages (from-to)	831-836
Number of pages	6
Journal	Biological Psychiatry
Volume	38
Issue number	12
DOIs	https://doi.org/10.1016/0006-3223(95)00070-4
State	Published - Dec 15 1995
Externally published	Yes

Keywords

Alcoholism
REM sleep
amphetamine
cocaine
total sleep time
withdrawal

ASJC Scopus subject areas

Biological Psychiatry

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10.1016/0006-3223(95)00070-4

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title = "Polygraphic sleep measures differentiate alcoholics and stimulant abusers during short-term abstinence",

abstract = "We hypothesized that stimulant abusers would sleep more and have more rapid eye movement (REM) sleep than primary alcoholics during acute withdrawal (first 10 days drug free) but would have opposite patterns during subacute withdrawal (days 11-14 drug free). We compared polygraphic sleep patterns during acute withdrawal (days 3-10) for 7 stimulant abusers and 8 alcoholics and during subacute withdrawal (days 11-14) for 7 different stimulant abusers and 8 different alcoholics. For comparison purposes, a group of normal controls from our preexisting database were matched for age and gender. Two statistically significant interactions were found: consistent with our hypothesis, stimulant abusers showed greater total sleep (TST) and REM sleep during acute withdrawal than subacute withdrawal, compared with alcoholics. In contrast, alcoholics showed less TST and REM sleep during acute withdrawal than during subacute withdrawal. Our polygraphic sleep data support the hypothesis that physiological withdrawal differs in alcoholics compared with stimulant abusers. Different mechanisms may underlie withdrawal in these two substances.",

keywords = "Alcoholism, REM sleep, amphetamine, cocaine, total sleep time, withdrawal",

author = "Thompson, {Peter M.} and Gillin, {J. Christian} and Shahrokh Golshan and Michael Irwin",

note = "Funding Information: Marc Schuckit, M.D., Director of the Alcohol Research Center, made significant contributions to this study through the recruitment, research evaluation, and clinical management of the alcoholic patients. We appreciate Kathy Resovsky, R.N., Caroline Ruiz, Anna Demodena, and Lesley Wetherell for their assistance in the collection and statistical analysis of the sleep records. This study was partially supported by a VA Merit grant (JCG), the Alcohol Research Center, the UCSD Mental Health Clinical Research Center (MH 30914), the UCSD Fellowship in Clinical Psychopharmacology and Psychobiology (MH 18399), MH 38738, and the UCSD General Clinical Research Center (MO1 RR00827),",

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AU - Thompson, Peter M.

AU - Gillin, J. Christian

AU - Golshan, Shahrokh

AU - Irwin, Michael

N1 - Funding Information: Marc Schuckit, M.D., Director of the Alcohol Research Center, made significant contributions to this study through the recruitment, research evaluation, and clinical management of the alcoholic patients. We appreciate Kathy Resovsky, R.N., Caroline Ruiz, Anna Demodena, and Lesley Wetherell for their assistance in the collection and statistical analysis of the sleep records. This study was partially supported by a VA Merit grant (JCG), the Alcohol Research Center, the UCSD Mental Health Clinical Research Center (MH 30914), the UCSD Fellowship in Clinical Psychopharmacology and Psychobiology (MH 18399), MH 38738, and the UCSD General Clinical Research Center (MO1 RR00827),

PY - 1995/12/15

Y1 - 1995/12/15

N2 - We hypothesized that stimulant abusers would sleep more and have more rapid eye movement (REM) sleep than primary alcoholics during acute withdrawal (first 10 days drug free) but would have opposite patterns during subacute withdrawal (days 11-14 drug free). We compared polygraphic sleep patterns during acute withdrawal (days 3-10) for 7 stimulant abusers and 8 alcoholics and during subacute withdrawal (days 11-14) for 7 different stimulant abusers and 8 different alcoholics. For comparison purposes, a group of normal controls from our preexisting database were matched for age and gender. Two statistically significant interactions were found: consistent with our hypothesis, stimulant abusers showed greater total sleep (TST) and REM sleep during acute withdrawal than subacute withdrawal, compared with alcoholics. In contrast, alcoholics showed less TST and REM sleep during acute withdrawal than during subacute withdrawal. Our polygraphic sleep data support the hypothesis that physiological withdrawal differs in alcoholics compared with stimulant abusers. Different mechanisms may underlie withdrawal in these two substances.

AB - We hypothesized that stimulant abusers would sleep more and have more rapid eye movement (REM) sleep than primary alcoholics during acute withdrawal (first 10 days drug free) but would have opposite patterns during subacute withdrawal (days 11-14 drug free). We compared polygraphic sleep patterns during acute withdrawal (days 3-10) for 7 stimulant abusers and 8 alcoholics and during subacute withdrawal (days 11-14) for 7 different stimulant abusers and 8 different alcoholics. For comparison purposes, a group of normal controls from our preexisting database were matched for age and gender. Two statistically significant interactions were found: consistent with our hypothesis, stimulant abusers showed greater total sleep (TST) and REM sleep during acute withdrawal than subacute withdrawal, compared with alcoholics. In contrast, alcoholics showed less TST and REM sleep during acute withdrawal than during subacute withdrawal. Our polygraphic sleep data support the hypothesis that physiological withdrawal differs in alcoholics compared with stimulant abusers. Different mechanisms may underlie withdrawal in these two substances.

KW - Alcoholism

KW - REM sleep

KW - amphetamine

KW - cocaine

KW - total sleep time

KW - withdrawal

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Polygraphic sleep measures differentiate alcoholics and stimulant abusers during short-term abstinence

Abstract

Keywords

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