Polygenic risk of ischemic stroke is associated with cognitive ability

Sarah E. Harris, Rainer Malik, Riccardo Marioni, Archie Campbell, Sudha Seshadri, Bradford B. Worrall, Cathie L.M. Sudlow, Caroline Hayward, Mark E. Bastin, John M. Starr, David J. Porteous, Joanna M. Wardlaw, Ian J. Deary

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: We investigated the correlation between polygenic risk of ischemic stroke (and its subtypes) and cognitive ability in 3 relatively healthy Scottish cohorts: the Lothian Birth Cohort 1936 (LBC1936), the Lothian Birth Cohort 1921 (LBC1921), and Generation Scotland: Scottish Family Health Study (GS). Methods: Polygenic risk scores for ischemic stroke were created in LBC1936 (n 1005), LBC1921 (n 517), and GS (n 6,815) using genome-wide association study summary data from the METASTROKE collaboration. We investigated whether the polygenic risk scores correlate with cognitive ability in the 3 cohorts. Results: In the largest cohort, GS, polygenic risk of all ischemic stroke, small vessel disease stroke, and large vessel disease stroke, but not cardioembolic stroke, were correlated with both fluid and crystallized cognitive abilities. The highest correlation was between a polygenic risk score for all ischemic stroke and general cognitive ability (r -0.070, p 1.95 × 10 -8). Few correlations were identified in LBC1936 and LBC1921, but a meta-analysis of all 3 cohorts supported the correlation between polygenic risk of ischemic stroke and cognitive ability. Conclusions: The findings from this study indicate that even in the absence of stroke, being at high polygenic risk of ischemic stroke is associated with lower cognitive ability.

Original languageEnglish (US)
Pages (from-to)611-618
Number of pages8
JournalNeurology
Volume86
Issue number7
DOIs
StatePublished - Feb 16 2016
Externally publishedYes

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Stroke
Parturition
Family Health
Genome-Wide Association Study
Scotland
Meta-Analysis

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Harris, S. E., Malik, R., Marioni, R., Campbell, A., Seshadri, S., Worrall, B. B., ... Deary, I. J. (2016). Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology, 86(7), 611-618. https://doi.org/10.1212/WNL.0000000000002306

Polygenic risk of ischemic stroke is associated with cognitive ability. / Harris, Sarah E.; Malik, Rainer; Marioni, Riccardo; Campbell, Archie; Seshadri, Sudha; Worrall, Bradford B.; Sudlow, Cathie L.M.; Hayward, Caroline; Bastin, Mark E.; Starr, John M.; Porteous, David J.; Wardlaw, Joanna M.; Deary, Ian J.

In: Neurology, Vol. 86, No. 7, 16.02.2016, p. 611-618.

Research output: Contribution to journalArticle

Harris, SE, Malik, R, Marioni, R, Campbell, A, Seshadri, S, Worrall, BB, Sudlow, CLM, Hayward, C, Bastin, ME, Starr, JM, Porteous, DJ, Wardlaw, JM & Deary, IJ 2016, 'Polygenic risk of ischemic stroke is associated with cognitive ability', Neurology, vol. 86, no. 7, pp. 611-618. https://doi.org/10.1212/WNL.0000000000002306
Harris SE, Malik R, Marioni R, Campbell A, Seshadri S, Worrall BB et al. Polygenic risk of ischemic stroke is associated with cognitive ability. Neurology. 2016 Feb 16;86(7):611-618. https://doi.org/10.1212/WNL.0000000000002306
Harris, Sarah E. ; Malik, Rainer ; Marioni, Riccardo ; Campbell, Archie ; Seshadri, Sudha ; Worrall, Bradford B. ; Sudlow, Cathie L.M. ; Hayward, Caroline ; Bastin, Mark E. ; Starr, John M. ; Porteous, David J. ; Wardlaw, Joanna M. ; Deary, Ian J. / Polygenic risk of ischemic stroke is associated with cognitive ability. In: Neurology. 2016 ; Vol. 86, No. 7. pp. 611-618.
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