Abstract
Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, MZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GM susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4047-4057 |
| Number of pages | 11 |
| Journal | Journal of Immunology |
| Volume | 195 |
| Issue number | 9 |
| State | Published - Nov 2015 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology