Polycystic ovarian syndrome and the risk of cardiovascular disease and thrombosis.

Winifred Mak, Anuja Dokras

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with multiple comorbidities such as diabetes, dyslipidemia, hypertension, and metabolic syndrome, all of which predispose women with PCOS to early atherosclerosis. Women with PCOS also have a higher prevalence of subclinical atherosclerosis, as reflected in dysregulation of endothelial function, increased carotid intimal-medial thickness, and presence of coronary artery calcification. Preliminary data indicate that serum biomarkers of cardiovascular disease such as high-sensitivity C-reactive protein, homocysteine, and adiponectin are abnormal in women with PCOS. There is limited data on abnormalities in the coagulation and fibrinolytic systems, however. The risk of venous thrombosis is unclear in the PCOS population, and further studies are urgently required to address whether first-line treatment for PCOS with oral contraceptive pills is advisable. (c) Thieme Medical Publishers.

Original languageEnglish (US)
Pages (from-to)613-620
Number of pages8
JournalSeminars in Thrombosis and Hemostasis
Issue number7
StatePublished - Oct 2009
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology


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